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AB224723

Anti-VASH2 antibody

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(4 Publications)

Rabbit Polyclonal VASH2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human VASH2.

View Alternative Names

VASHL, VASH2, Tubulinyl-Tyr carboxypeptidase 2, Vasohibin-2, Vasohibin-like protein

1 Images
Western blot - Anti-VASH2 antibody (AB224723)
  • WB

Supplier Data

Western blot - Anti-VASH2 antibody (AB224723)

All lanes:

Western blot - Anti-VASH2 antibody (ab224723) at 1/2000 dilution

All lanes:

SH-SY5Y (human neuroblastoma cell line from bone marrow) cell lysate

Secondary

All lanes:

Goat Anti-Rabbit secondary antibody at 1/5000 dilution

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human VASH2.

Q86V25

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VASH2 also known as vasohibin-2 is a protein that acts as an angiogenesis modulator. It has a molecular mass of approximately 40 kDa. VASH2 gets expressed in several tissues including the placenta and ovary. The protein is involved in endothelial cell function due to its role in angiogenesis. VASH2 shows similarities to VASH1 another member of the vasohibin family but with distinct roles in vascular biology.
Biological function summary

VASH2 supports endothelial cell growth and promotes new blood vessel formation which is significant for tissue regeneration and repair processes. The protein often works as part of a complex with small vasohibin-binding protein (SVBP) which enhances its stability and activity. VASH2 facilitates processes that lead to the creation of vascular structures and modifies the extracellular environment through its enzymatic activity.

Pathways

VASH2 interacts with angiogenic signaling specifically the VEGF (vascular endothelial growth factor) pathway. VASH2 has connections with VEGF receptors influencing vascular growth and remodeling. The protein also influences the Notch signaling pathway which is critical for maintaining balance between vascular proliferation and differentiation. These pathways establish VASH2's role in promoting angiogenic responses.

VASH2 is linked to cancer and diabetic retinopathy. Increased expression of VASH2 associates with tumor growth and metastasis because the protein encourages angiogenesis that supplies tumors with nutrients and oxygen. In diabetic retinopathy VASH2 can exacerbate abnormal blood vessel formation which can lead to vision impairment. VASH2 interacts with VEGF during these conditions highlighting its role in pathological angiogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed : 29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed : 31171830). Acts as an activator of angiogenesis : expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed : 19204325). Plays a role in axon formation (PubMed : 31235911).
See full target information VASH2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Tohoku journal of experimental medicine : PubMed41034039

2025

Expressions of VEGF, Vasohibin-1, and Vasohibin-2 in Benign Parotid Gland Tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Yutaka Tateda,Takahiro Suzuki,Teruyuki Sato,Kazue Ise,Hiroki Shimada,Yasuhiro Nakamura,Nobuo Ohta

Scientific reports 15:22207 PubMed40593088

2025

Homocysteine promotes cardiomyocyte hypertrophy through inhibiting β-catenin/ FUNDC1 mediated mitophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Yanping Lei,Hengjing Hu,Huifang Tang,Hui Sun,Rui Liu,Yue Zhao

International journal of molecular sciences 24: PubMed36768957

2023

Altered Posttranslational Modification of Microtubules Contributes to Disturbed Enterocyte Morphology in Celiac Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Sebastian Stricker,Manuel Müller,Klaus-Peter Zimmer,Ralf Jacob

Nature 594:560-565 PubMed34040253

2021

MARK4 controls ischaemic heart failure through microtubule detyrosination.

Applications

Unspecified application

Species

Unspecified reactive species

Xian Yu,Xiao Chen,Mamta Amrute-Nayak,Edward Allgeyer,Aite Zhao,Hannah Chenoweth,Marc Clement,James Harrison,Christian Doreth,George Sirinakis,Thomas Krieg,Huiyu Zhou,Hongda Huang,Kiyotaka Tokuraku,Daniel St Johnston,Ziad Mallat,Xuan Li
View all publications
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