Anti-VASH2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

VASH2 also known as vasohibin-2 is a protein that acts as an angiogenesis modulator. It has a molecular mass of approximately 40 kDa. VASH2 gets expressed in several tissues including the placenta and ovary. The protein is involved in endothelial cell function due to its role in angiogenesis. VASH2 shows similarities to VASH1 another member of the vasohibin family but with distinct roles in vascular biology.

Biological function summary

VASH2 supports endothelial cell growth and promotes new blood vessel formation which is significant for tissue regeneration and repair processes. The protein often works as part of a complex with small vasohibin-binding protein (SVBP) which enhances its stability and activity. VASH2 facilitates processes that lead to the creation of vascular structures and modifies the extracellular environment through its enzymatic activity.

Pathways

VASH2 interacts with angiogenic signaling specifically the VEGF (vascular endothelial growth factor) pathway. VASH2 has connections with VEGF receptors influencing vascular growth and remodeling. The protein also influences the Notch signaling pathway which is critical for maintaining balance between vascular proliferation and differentiation. These pathways establish VASH2's role in promoting angiogenic responses.

Associated diseases and disorders

VASH2 is linked to cancer and diabetic retinopathy. Increased expression of VASH2 associates with tumor growth and metastasis because the protein encourages angiogenesis that supplies tumors with nutrients and oxygen. In diabetic retinopathy VASH2 can exacerbate abnormal blood vessel formation which can lead to vision impairment. VASH2 interacts with VEGF during these conditions highlighting its role in pathological angiogenesis.