AB231227

Anti-VE Cadherin antibody

Name: Anti-VE Cadherin antibody (ab231227) | Abcam
Brand: Abcam Limited
SKU: AB231227
Price: 515 USD
Availability: InStock

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(15 Publications)

Rabbit Polyclonal VE Cadherin antibody. Suitable for WB and reacts with Rat samples. Cited in 15 publications.

2 Images

Supplier Data

Western blot - Anti-VE Cadherin antibody (AB231227)

All lanes:

Western blot - Anti-VE Cadherin antibody (ab231227) at 5 µg/mL

All lanes:

Rat serum

Predicted band size: 88 kDa

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Supplier Data

Western blot - Anti-VE Cadherin antibody (AB231227)

All lanes:

Western blot - Anti-VE Cadherin antibody (ab231227) at 5 µg/mL

All lanes:

Recombinant rat VE Cadherin protein

Predicted band size: 88 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VE Cadherin also known as CD144 or Cadherin-5 is a protein of about 135 kDa involved in cell adhesion. It is a transmembrane protein characterized by its presence at endothelial cell junctions. VE Cadherin belongs to the cadherin superfamily and its expression predominantly occurs in vascular endothelial cells. This protein facilitates the adhesion between adjacent endothelial cells maintaining the integrity of endothelial barriers.

Biological function summary

VE Cadherin performs essential roles in vascular development and permeability. It is a component of adherens junctions and connects with catenins to mediate cell-cell adhesion through calcium-dependent binding. This protein's adhesive function is critical for blood vessel maturation and response to inflammatory stimuli. Altering VE Cadherin expression impacts vascular stability and endothelial cell layering.

Pathways

VE Cadherin interacts with the Wnt and VEGF signaling pathways. It plays a role in the regulation of endothelial cell survival and migration. The interaction with β-catenin is important in the Wnt pathway influencing the transcription of target genes that modulate cell behavior. In the VEGF pathway VE Cadherin's association with protein kinase C highlights its involvement in endothelial permeability and angiogenesis processes.

VE Cadherin dysregulation links to cancer progression and atherosclerosis. Its role in maintaining endothelial barrier integrity implicates it in tumor metastasis where disrupted cell adhesion facilitates cancer cell dissemination. Additionally altered VE Cadherin expression or function associates with atherosclerotic disease where damaged vascular endothelium leads to plaque formation. The connection of VE Cadherin with β-catenin in these conditions highlights its significance in pathological angiogenesis and vascular remodeling.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

See full target information VE Cadherin

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical and translational hepatology 12:496-504 PubMed38779522

2024

The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyang Zeng,Yuhao Lei,Chunyong Yang,Xianfeng Wu,Liang Zhang,Zhiyong Yang,Lin Chen,Xiaobo Wang,Karine Belguise,Yujie Li,Bin Yi

In vitro cellular & developmental biology. Animal 60:793-804 PubMed38409639

2024

TGFβ2 mediates oxidative stress-induced epithelial-to-mesenchymal transition of bladder smooth muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Jingwen Geng,Xiaofan Zhang,Yansong Zhang,Xiaojia Meng,Jinqi Sun,Bo Zhou,Jun Ma

Acta biomaterialia 166:133-146 PubMed37149079

2023

The cell-assembled extracellular matrix: A focus on the storage stability and terminal sterilization of this human "bio" material.

Applications

Unspecified application

Species

Unspecified reactive species

Diane Potart,Maude Gluais,Alexandra Gaubert,Nicolas Da Silva,Marie Hourques,Marie Sarrazin,Julien Izotte,Léa Mora Charrot,Nicolas L'Heureux

Military Medical Research 10:13 PubMed36907884

2023

Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Sen Zhang,Yi-Yan Liu,Shuang-Shuang He,Dai-Qin Bao,Hong-Chen Wang,Jie Zhang,Xiao-Yong Peng,Jia-Tao Zang,Yu Zhu,Yue Wu,Qing-Hui Li,Tao Li,Liang-Ming Liu

Evidence-based complementary and alternative medicine : eCAM 2023:8269356 PubMed36865750

2023

METTL3 Promotes Endothelium-Mesenchymal Transition of Pulmonary Artery Endothelial Cells by Regulating TRPC6/Calcineurin/NFAT Signaling Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Chunchu Kong,Fuxiu Zhang,Ruicheng Hu,Lile Wang

BioMed research international 2022:8717950 PubMed36060145

2022

The Protective Effect of Sulodexide on Acute Lung Injury Induced by a Murine Model of Obstructive Jaundice.

Applications

Unspecified application

Species

Unspecified reactive species

Penglei Ma,Yue Long,Qiang Fu,Yanhong Liu,Yitian Yang,Weixing Zhao,Qiangwei Liu,Yang Li,Weidong Mi

Computational and mathematical methods in medicine 2022:9397478 PubMed35495890

2022

The Effect of Qingre Huayu Recipe on Wound Healing after Anal Fistulotomy in Sprague-Dawley Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Jiazhi Gao,Jiandong Wang,Ping Chen,Peilin Ding,Liang Tian,Biao Liang,Zhan Shi

Kidney & blood pressure research 47:256-269 PubMed35016182

2022

Ulinastatin Improves Renal Microcirculation by Protecting Endothelial Cells and Inhibiting Autophagy in a Septic Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Li,Xiaojun Ji,Jingfeng Liu,Xinjie Guo,Ran Pang,Haizhou Zhuang,Lei Dong,Meili Duan,Ang Li

Disease markers 2022:1839341 PubMed35059042

2022

LTB4 Promotes Acute Lung Injury via Upregulating the PLC-1/TLR4/NF-B Pathway in One-Lung Ventilation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Luo,Qingjie Ma,Heng Tang,Xi Zou,Xin Guo,Yuzhen Hu,Kejiang Zhou,Rui Liu

Cell cycle (Georgetown, Tex.) 20:1692-1707 PubMed34334113

2021

ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Qingbao Guo,Manli Xie,Miao Guo,Feiping Yan,Lihong Li,Rui Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-VE Cadherin antibody

Western blot - Anti-VE Cadherin antibody (AB231227)

Western blot - Anti-VE Cadherin antibody (AB231227)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (15)

Product promise