Rat Monoclonal VEGF Receptor 3 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Flt4.
Images
![Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (AB51874), expandable thumbnail](https://content.abcam.com/products/images/vegf-receptor-3-antibody-rm0003-5f63-ab51874--immunohistochemistry-paraffin-embedded-sections-img38689.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (AB51874)")
Publications
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- Experimental and therapeutic medicine 22:11022021Sema4C modulates the migration of primary tumor-associated lymphatic endothelial cells via an ERK-mediated pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJin Peng,Xijiang Liu,Chengcheng Li,Min Gao,Hongyan WangPubMed 34504556
- Scientific reports 11:131442021Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGautier Follain,Naël Osmani,Valentin Gensbittel,Nandini Asokan,Annabel Larnicol,Luc Mercier,Maria Jesus Garcia-Leon,Ignacio Busnelli,Angelique Pichot,Nicodème Paul,Raphaël Carapito,Seiamak Bahram,Olivier Lefebvre,Jacky G GoetzPubMed 34162963
- Oncotarget 7:47536-475552016Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhenqiang Sun,Chunlin Ou,Weiguo Ren,Xiang Xie,Xiayu Li,Guiyuan LiPubMed 27286457
- Circulation 133:1484-97; discussion 14972016Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOrianne Henri et. al.PubMed 26933083
- PLoS genetics 11:e10053242015Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJeong Ae Park,Dong Young Kim,Young-Myeong Kim,In-Kyu Lee,Young-Guen KwonPubMed 26147525
Key facts
- Isotype
- IgG2
- Host species
- Rat
- Storage buffer
Constituents: PBS
- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Mouse Flt4. Database link P35917
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Mouse | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes Use at 1/100-1/500 dilution |
Associated Products
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6 products for Alternative Product
Target data
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
Alternative names
Flt-4, Vegfr3, Flt4, Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, FLT-4
Recommended products
Rat Monoclonal VEGF Receptor 3 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Flt4.
Key facts
- Isotype
- IgG2
- Host species
- Rat
- Storage buffer
Constituents: PBS
- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Mouse Flt4. Database link P35917
- Clone number
- RM0003-5F63
- Purification technique
- Affinity purification Protein G
- Specificity
No cross reactivity to mouse VEGFR1 and VEGFR2.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
VEGF Receptor 3 also known as FLT-4 is a protein essential for lymphatic development and is expressed mainly in lymphatic endothelial cells. This receptor has a molecular mass of approximately 195 kDa. VEGF Receptor 3 belongs to the tyrosine kinase family and binds with high affinity to its ligands VEGF-C and VEGF-D. These interactions lead to the activation of intracellular signaling cascades that promote cell proliferation migration and survival.
- Biological function summary
The VEGF Receptor 3 acts as an important regulator of lymphangiogenesis which is the growth of new lymphatic vessels from pre-existing ones. It is not typically part of larger protein complexes but it works closely with its ligands to facilitate the processes associated with lymph vessel formation and function. Proper activity of VEGF Receptor 3 is necessary for maintaining normal lymphatic vessel remodeling and function during development and in some adult tissues.
- Pathways
The receptor is involved in the VEGF signaling pathway which plays an important role in vascular and lymphatic development. This pathway intersects with others like the PI3K/AKT pathway a critical mediator of cell growth and survival. VEGF Receptor 3 interacts with related receptors such as VEGF Receptor 2 in these pathways to regulate complex and essential physiological processes.
- Associated diseases and disorders
VEGF Receptor 3 has been linked to lymphedema which is swelling due to lymphatic system dysfunction and certain cancers where excessive angiogenesis occurs. Mutations or dysregulations in the receptor's signaling can lead to these conditions. In cancer for instance VEGF Receptor 3 along with its associated protein VEGF-C can promote tumor lymphangiogenesis facilitating metastasis. Antagonists like anti-VEGF therapies target these receptors to inhibit tumor progression and manage these disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (ab51874), expandable thumbnail](https://content.abcam.com/products/images/vegf-receptor-3-antibody-rm0003-5f63-ab51874--immunohistochemistry-paraffin-embedded-sections-img38689.jpg "Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (ab51874)")
Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (ab51874)
ab51874 at 1/500 dilution, staining VEGF Receptor 3 in mouse heart tissue section by Immunohistochemistry (paraffin-embedded sections).
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