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AB106512

Anti-VEGFC antibody [9/E7]

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(5 Publications)

Mouse Monoclonal VEGFC antibody. Suitable for IHC-P, IHC-Fr and reacts with Human, Rat samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VEGFC aa 100-250.

View Alternative Names

Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Vascular endothelial growth factor-related protein, Flt4-L, VRP, VEGFC

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFC antibody [9/E7] (AB106512)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFC antibody [9/E7] (AB106512)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue sections labelling VEGFC with ab106512.

Immunohistochemistry (Frozen sections) - Anti-VEGFC antibody [9/E7] (AB106512)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-VEGFC antibody [9/E7] (AB106512)

Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.

Immunohistochemistry (Frozen sections) - Anti-VEGFC antibody [9/E7] (AB106512)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-VEGFC antibody [9/E7] (AB106512)

Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

9/E7

Isotype

IgG2a

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Human VEGFC aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

P49767

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-10 µg/mL", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "2-10 µg/mL", "IHCFr-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in water
Purification technique
Affinity purification Protein G
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VEGFC also known as Vascular Endothelial Growth Factor C is a member of the VEGF family involved in angiogenesis and lymphangiogenesis. It has a molecular mass of approximately 35 kDa. VEGFC is expressed in various tissues with high levels in the heart lung and muscle. It acts primarily through its interaction with the VEGFR-3 receptor stimulating the formation of blood and lymphatic vessels. This protein plays an important role in the development and maintenance of the circulatory and lymphatic systems.
Biological function summary

VEGFC contributes to the regulation of vascular and lymphatic endothelial cell functions. It is not known to be part of a larger protein complex but exerts its functions through interactions with receptors such as VEGFR-3. By promoting cell proliferation and migration VEGFC assists in the repair and regeneration of tissues. Its role in fluid balance is essential as it helps maintain tissue equilibrium and immune function.

Pathways

VEGFC is integral to the VEGF signaling and lymphatic vessel development pathways. Within these processes VEGFC works alongside other proteins such as VEGFA and VEGFB to modulate vascular permeability and vessel formation. The interaction between VEGFC and the VEGFR-3 receptor specifically mediates lymphatic endothelial cell activation and function linking it to vital physiological processes like inflammation and tissue repair.

VEGFC is associated with cancer and lymphedema. Its role in promoting angiogenesis is critical in tumor growth and metastasis with its overexpression often linked to cancer progression. Furthermore insufficient VEGFC activity contributes to the development of lymphedema due to inadequate lymphatic drainage. In cancer pathology VEGFC works together with VEGFR-3 contributing to the abnormal growth of lymphatic vessels which in turn facilitates cancer cell dissemination.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
See full target information VEGFC
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 11:3820-3836 PubMed35434898

2022

Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects.

Applications

Unspecified application

Species

Unspecified reactive species

Ian S Miller,Sonja Khan,Liam P Shiels,Sudipto Das,Alice C O' Farrell,Kate Connor,Adam Lafferty,Bruce Moran,Claudio Isella,Paul Loadman,Emer Conroy,Susan Cohrs,Roger Schibli,Robert S Kerbel,William M Gallagher,Elisabetta Marangoni,Kathleen Bennett,Darran P O' Connor,Róisín M Dwyer,Annette T Byrne

Cancer medicine 10:1485-1500 PubMed33611864

2021

An immature inhibin-α-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Shinya Kusumoto,Masako Kurashige,Kenji Ohshima,Shinichiro Tahara,Takahiro Matsui,Satoshi Nojima,Satoshi Hattori,Eiichi Morii

Stem cell research & therapy 11:485 PubMed33198798

2020

Momordica charantia polysaccharides modulate the differentiation of neural stem cells via SIRT1/Β-catenin axis in cerebral ischemia/reperfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoli Hu,Fengying Li,Xiaoling Zhou,Feng Zhang,Linyan Huang,Bing Gu,Jiangang Shen,Suhua Qi

Acta neuropathologica communications 8:16 PubMed32059751

2020

Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanhui Liu,Chuang Gao,Jiangyuan Yuan,Tangtang Xiang,Zhitao Gong,Hongliang Luo,Weiwei Jiang,Yiming Song,Jinhao Huang,Wei Quan,Dong Wang,Ye Tian,Xintong Ge,Ping Lei,Jianning Zhang,Rongcai Jiang

Biomaterials 190-191:63-75 PubMed30396040

2018

A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

Applications

Unspecified application

Species

Unspecified reactive species

Daniela Loessner,Anja Rockstroh,Ali Shokoohmand,Boris M Holzapfel,Ferdinand Wagner,Jeremy Baldwin,Melanie Boxberg,Barbara Schmalfeldt,Ernst Lengyel,Judith A Clements,Dietmar W Hutmacher
View all publications
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Product promise

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