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AB124523

Anti-VENTX antibody

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(1 Publication)

Rabbit Polyclonal VENTX antibody. Suitable for WB and reacts with Rat, Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human VENTX.

View Alternative Names

HPX42B, VENTX2, VENTX, Homeobox protein VENTX, VENT homeobox homolog, VENT-like homeobox protein 2

1 Images
Western blot - Anti-VENTX antibody (AB124523)
  • WB

Unknown

Western blot - Anti-VENTX antibody (AB124523)

All lanes:

Western blot - Anti-VENTX antibody (ab124523) at 4 µg/mL

Lanes 1 - 2:

Jurkat cell lysate

Lane 3:

3T3 cell lysate

Lane 4:

Rat kidney tissue lysate

Predicted band size: 27 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human VENTX. The exact immunogen used to generate this antibody is proprietary information.

O95231

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3286 VENTX Antibody. 3286-100 is the same size as the 100 µg size of ab124523.

The antibody solution should be gently mixed before use.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.15% EDTA
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VENTX also known as Vent homeobox or VENTX1 serves as a transcription factor involved in gene regulation processes. This protein has an approximate molecular mass of 29 kDa. It predominantly expresses in hematopoietic tissues indicating its role in blood cell development and function. VENTX possesses a homeobox DNA-binding domain that enables it to bind to specific DNA sequences and modulate the transcription of target genes influencing cell differentiation and proliferation.
Biological function summary

VENTX regulates cellular functions and developmental processes. It is not part of a larger complex but it functions independently to impact hematopoiesis or blood cell formation. The transcription factor influences stages of myeloid lineage differentiation which is necessary for the production of several immune cell types. By controlling the expression of various genes VENTX impacts cell cycle progression apoptosis and immune responses.

Pathways

VENTX plays a pivotal role in the Notch signaling and Wnt signaling pathways. These two pathways are important for the regulation of cell fate decisions proliferation and apoptosis. In the Notch pathway VENTX interacts with other transcription factors such as TCF7 which guides the differentiation of hematopoietic stem cells. In the context of the Wnt pathway VENTX modulates signals that are important for stem cell maintenance and differentiation within the bone marrow and peripheral immune tissues.

VENTX implicates in conditions like leukemia and myelodysplastic syndromes. Overexpression or aberrant regulation of this transcription factor can contribute to malignant transformation and uncontrolled proliferation of myeloid cells. VENTX shows interaction with proteins such as RUNX1 which is also implicated in leukemogenesis. Its dysregulation can result in ineffective hematopoiesis linking it to the pathophysiology of these hematological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in ventralization.
See full target information VENTX
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International heart journal 63:602-611 PubMed35650160

2022

Downregulation of lncRNA MALAT1 Inhibits Angiotensin II-induced Hypertrophic Effects of Cardiomyocytes by Regulating SIRT4 via miR-93-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Huanchun Ji,Jingxian Qu,Wei Peng,Long Yang
View all publications
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Product promise

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