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AB229237

Anti-VEPH1 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal VEPH1 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human VEPH1.

View Alternative Names

KIAA1692, VEPH, VEPH1, Ventricular zone-expressed PH domain-containing protein homolog 1, Protein melted

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEPH1 antibody - N-terminal (AB229237)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEPH1 antibody - N-terminal (AB229237)

Paraffin-embedded mouse stomach tissue stained for VEPH1 using ab229237 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-VEPH1 antibody - N-terminal (AB229237)
  • WB

Supplier Data

Western blot - Anti-VEPH1 antibody - N-terminal (AB229237)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-VEPH1 antibody - N-terminal (ab229237) at 1/1000 dilution

All lanes:

Mouse heart extract at 50 µg

Predicted band size: 95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human VEPH1. The exact immunogen used to generate this antibody is proprietary information.

Q14D04

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Alternative Products

Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VEPH1 also known by the alternate name VPS37-like is a protein with an approximate molecular mass of 55 kDa. It functions mechanically as a regulator of signal transduction processes and also serves a role in the endosomal sorting complex required for transport (ESCRT) pathway. Predominantly localized in the cytoplasm VEPH1 shows expression in a variety of tissues with notable levels found in brain and testis. This distribution suggests that it could be involved in a wide range of cellular processes related to these tissues.
Biological function summary

VEPH1 acts as a modulator of cellular signaling processes influencing cell growth and differentiation. It is not part of a known protein complex but interacts with important signaling molecules in the cell. VEPH1 plays a role in maintaining cellular homeostasis and is thought to participate in pathways regulating cell cycle and apoptosis. These functions highlight its potential importance in cell development and repair mechanisms.

Pathways

Research reveals VEPH1 is involved in the MAPK/ERK and PI3K/AKT signaling pathways which are critical for cell survival and proliferation. It interacts with proteins such as MEK and AKT which are central to these pathways. By influencing these proteins VEPH1 helps mediate various downstream effects on cellular function including responses to growth factors and stress signals.

The dysregulation of VEPH1 has been implicated in cancer and neurodegenerative diseases. Alterations in VEPH1 levels have shown association with certain types of cancer such as glioblastoma potentially due to its involvement in cell growth pathways. Similarly its connections with other proteins such as those in the PI3K/AKT pathway indicate a possible role in neurodegenerative disorders where cell survival signals are disrupted. Understanding these relationships may pave the way for therapeutic interventions targeting VEPH1-related pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.
See full target information VEPH1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 13:857774 PubMed35592424

2022

Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Jian Zhang,Kun-Peng Wang,Yun-Peng Huang,Chong Jin,Hao Jiang,Li Xiong,Zhao-Yi Chen,Yu Wen,Zhong-Tao Liu,Jing-Gang Mo
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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