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AB42806

Anti-VEZT antibody

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(1 Publication)

Rabbit Polyclonal VEZT antibody. Suitable for IP, ELISA, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human VEZT.

View Alternative Names

Vezatin, VEZT

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB, ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human VEZT.

Q9HBM0

Specificity

This antibody reacts specificly with vezatin protein

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VEZT also known as vezatin is a membrane-associated molecule that plays significant mechanical roles within cells. It has an approximate mass of 85 kDa. VEZT is widely expressed in various tissues with notably high expression in epithelial tissues. The protein primarily localizes at adherens junctions where it interacts with the cell cytoskeleton contributing to cellular stability and organization.
Biological function summary

This protein facilitates cell adhesion and signaling. VEZT forms part of a complex with myosin VIIA which helps in linking cell surface receptors to the actin cytoskeleton. This interaction maintains the structural integrity of tissues and supports cellular processes such as migration and morphogenesis. VEZT's involvement in these processes highlights its function in maintaining proper cellular architecture and communication.

Pathways

VEZT operates within the Wnt signaling pathway a fundamental pathway in controlling cell proliferation and differentiation. It interacts with proteins like beta-catenin within this context. VEZT also plays a role in the cadherin-catenin complex important for cell-cell adhesion. Its interaction with proteins such as E-cadherin in these pathways emphasizes its role in ensuring epithelial cell tissue integrity and function.

VEZT has been linked to cancer progression notably in gastric and breast cancers. Altered expression of VEZT correlates with changes in cell adhesion properties aiding in tumor cell invasion and metastasis. VEZT interacts with proteins such as E-cadherin where disruptions can contribute to the loss of cell adhesion a hallmark of many cancers. Understanding VEZT's role in these pathological conditions can lead to potential therapeutic strategies targeting its molecular interactions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.. (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.
See full target information VEZT
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 12:5741-5751 PubMed33042453

2020

Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Ma,Zaiyi Li,Sujuan Xi,Quan Guo,Panlin Zhao,Weihao Li,Jing Ai,Xiaoxuan Chen
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Product promise

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