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AB254938

Anti-VGLL3 antibody

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(1 Publication)

Rabbit Polyclonal VGLL3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transcription cofactor vestigial-like protein 3 aa 1-100.

View Alternative Names

Transcription cofactor vestigial-like protein 3, Vgl-3, VGLL3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-VGLL3 antibody (AB254938)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-VGLL3 antibody (AB254938)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling FAM5C using ab254938 at 4μg/ml (green) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human Transcription cofactor vestigial-like protein 3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

A8MV65

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VGLL3 or Vestigial-like family member 3 is a co-transcriptional factor with an estimated molecular mass of around 35 kDa. Researchers often refer to it by its alternate name without confusion. The protein primarily exists in the nucleus where it interacts with other transcriptional elements to modulate gene expression. VGLL3 shows high expression in certain tissues including skin and immune cells indicating its functional importance in these regions. It can engage TEAD transcription factors to regulate target genes.
Biological function summary

VGLL3 regulates cellular processes related to development and immune response. It functions as a transcriptional co-activator and can be part of protein complexes involving TEAD proteins to influence gene transcription. This association impacts tissue growth and cellular differentiation highlighting VGLL3's role in maintaining cellular homeostasis. Its activity can impact cellular pathways that are critical for normal biological functioning.

Pathways

VGLL3 shows significant involvement in Hippo signaling and immune response pathways. The Hippo pathway plays an essential role in controlling organ size and suppressing tumors where VGLL3 interacts with proteins such as YAP and TAZ to control cellular proliferation. Additionally VGLL3's involvement in immune pathways suggests its role in regulating immune cell activity and response which may connect it with other immune-responsive genes or proteins.

VGLL3 plays a role in autoimmune diseases and certain cancers. For autoimmune diseases VGLL3 has been linked to conditions like systemic lupus erythematosus where it affects immune pathway regulation. In cancer VGLL3's impact on the Hippo pathway can influence tumor growth making it a target for research in tumorigenesis. Its interaction with TEAD proteins in both contexts suggests a broader functional implication in disorders involving abnormal cell growth and immune regulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as a specific coactivator for the mammalian TEFs.
See full target information Transcription cofactor vestigial-like protein 3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:210 PubMed38172207

2024

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Feiyang Ma,Pei-Suen Tsou,Mehrnaz Gharaee-Kermani,Olesya Plazyo,Xianying Xing,Joseph Kirma,Rachael Wasikowski,Grace A Hile,Paul W Harms,Yanyun Jiang,Enze Xing,Mio Nakamura,Danielle Ochocki,William D Brodie,Shiv Pillai,Emanual Maverakis,Matteo Pellegrini,Robert L Modlin,John Varga,Lam C Tsoi,Robert Lafyatis,J Michelle Kahlenberg,Allison C Billi,Dinesh Khanna,Johann E Gudjonsson
View all publications
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