AB68262

Anti-VGLL3 antibody

Name: Anti-VGLL3 antibody (ab68262) | Abcam
Brand: Abcam Limited
SKU: AB68262
Price: 535 USD
Availability: InStock

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(4 Publications)

Mouse Polyclonal VGLL3 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Transcription cofactor vestigial-like protein 3.

View Alternative Names

Transcription cofactor vestigial-like protein 3, Vgl-3, VGLL3

1 Images

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Western blot - Anti-VGLL3 antibody (AB68262)

All lanes:

Western blot - Anti-VGLL3 antibody (ab68262) at 1/500 dilution

Lane 1:

VGLL3 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 36 kDa

Observed band size: 43 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Transcription cofactor vestigial-like protein 3.

A8MV65

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VGLL3 or Vestigial-like family member 3 is a co-transcriptional factor with an estimated molecular mass of around 35 kDa. Researchers often refer to it by its alternate name without confusion. The protein primarily exists in the nucleus where it interacts with other transcriptional elements to modulate gene expression. VGLL3 shows high expression in certain tissues including skin and immune cells indicating its functional importance in these regions. It can engage TEAD transcription factors to regulate target genes.

Biological function summary

VGLL3 regulates cellular processes related to development and immune response. It functions as a transcriptional co-activator and can be part of protein complexes involving TEAD proteins to influence gene transcription. This association impacts tissue growth and cellular differentiation highlighting VGLL3's role in maintaining cellular homeostasis. Its activity can impact cellular pathways that are critical for normal biological functioning.

Pathways

VGLL3 shows significant involvement in Hippo signaling and immune response pathways. The Hippo pathway plays an essential role in controlling organ size and suppressing tumors where VGLL3 interacts with proteins such as YAP and TAZ to control cellular proliferation. Additionally VGLL3's involvement in immune pathways suggests its role in regulating immune cell activity and response which may connect it with other immune-responsive genes or proteins.

VGLL3 plays a role in autoimmune diseases and certain cancers. For autoimmune diseases VGLL3 has been linked to conditions like systemic lupus erythematosus where it affects immune pathway regulation. In cancer VGLL3's impact on the Hippo pathway can influence tumor growth making it a target for research in tumorigenesis. Its interaction with TEAD proteins in both contexts suggests a broader functional implication in disorders involving abnormal cell growth and immune regulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

May act as a specific coactivator for the mammalian TEFs.

See full target information Transcription cofactor vestigial-like protein 3

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:12295 PubMed40210649

2025

Assessment of the toxic effect of benzalkonium chloride on human limbal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Prusek,Bartosz Sikora,Aleksandra Skubis-Sikora,Piotr Czekaj

Molecular and clinical oncology 22:13 PubMed39720459

2024

hsa_circ_0001508 as a new gene that may promote breast cancer progression via the miR‑505‑3p/HMGB1, VGLL3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe Sun,Wenjing Duan,Jinxian Qian,Liang Chen,Fei Ge

Cancer research 84:4283-4297 PubMed39356622

2024

Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Carolina Gemma,Chun-Fui Lai,Anup K Singh,Antonino Belfiore,Neil Portman,Heloisa Z Milioli,Manikandan Periyasamy,Sara Raafat,Alyssa J Nicholls,Claire M Davies,Naina R Patel,Georgia M Simmons,Hailing Fan,Van T M Nguyen,Luca Magnani,Emad Rakha,Lesley-Ann Martin,Elgene Lim,R Charles Coombes,Giancarlo Pruneri,Laki Buluwela,Simak Ali

Cells, tissues, organs 198:190-7 PubMed24247045

2013

Use of a silk fibroin-chitosan scaffold to construct a tissue-engineered corneal stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Linan Guan,Hongyan Ge,Xianling Tang,Sheng Su,Pei Tian,Nan Xiao,Hong Zhang,Lu Zhang,Ping Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-VGLL3 antibody

Western blot - Anti-VGLL3 antibody (AB68262)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise