Anti-VGLUT2 antibody [EPR25147-68] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

VGLUT2 also known as Vesicular Glutamate Transporter 2 or SLC17A6 plays a significant role in neurotransmission. This protein facilitates the transport of glutamate an excitatory neurotransmitter into synaptic vesicles in preparation for synaptic release. VGLUT2 has a molecular weight of approximately 61 kDa. Its expression appears particularly in the central nervous system including regions like the thalamus brainstem and some parts of the cerebral cortex.

Biological function summary

VGLUT2 is essential for proper glutamatergic signaling in neuronal communication. The protein does not form part of a larger complex but functions individually to maintain synaptic vesicle filling with glutamate. Normal glutamatergic synaptic transmission relies on VGLUT2’s ability to concentrate glutamate in synaptic vesicles. This concentration is necessary for effective excitatory signaling impacting processes such as synaptic plasticity learning and memory.

Pathways

VGLUT2 serves a critical function in neurotransmitter release and synaptic vesicle cycle. The protein actively transports glutamate into synaptic vesicles enabling its release into the synaptic cleft. VGLUT2 interacts closely with proteins like SNAREs that assist in vesicle docking and fusion. The protein also plays a functional role in the glutamatergic pathway which is important for excitatory neurotransmission in the brain.

Associated diseases and disorders

VGLUT2 holds relevance to conditions such as schizophrenia and epilepsy. Its dysregulation can alter glutamate levels potentially contributing to altered neuronal excitability and synaptic dysfunction. Studies link VGLUT2 with connected proteins like NMDA receptors which mediate excitatory postsynaptic potentials and are associated with glutamatergic signaling disruptions in these disorders. Alterations in the expression or function of VGLUT2 might influence susceptibility to these neuropsychiatric and neurological conditions.