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AB242067

violetFluor™ 450 Anti-KLRG1 antibody [2F1]

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(1 Publication)

Syrian hamster Monoclonal Klrg1 antibody - conjugated to violetFluor™ 450. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Klrg1 protein.
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Flow Cytometry - violetFluor™ 450 Anti-KLRG1 antibody [2F1] (AB242067)
  • Flow Cyt

Supplier Data

Flow Cytometry - violetFluor™ 450 Anti-KLRG1 antibody [2F1] (AB242067)

Flow cytometric analysis of mouse C57Bl/6 splenocyte cells staining KLRG1 using PE Anti-Mouse NK1.1 and 0.125 μg ab242067 (right panel) or 0.125 μg violetFluor™ 450 Syrian Hamster IgG isotype control (left panel).

Key facts

Host species

Syrian hamster

Clonality

Monoclonal

Clone number

2F1

Isotype

IgG

Conjugation

violetFluor™ 450

Excitation/Emission

Ex: 405nm, Em: 450nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>0.125 μg: The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from TCS.
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLRG1 also known as killer cell lectin-like receptor G1 is a protein with a mass of about 30 kDa. It functions mechanically as an inhibitory receptor on natural killer (NK) cells and subsets of T cells. KLRG1 binds to classical cadherins like E-cadherin and N-cadherin modulating immune cell activity. Expression of KLRG1 is found mainly on mature NK cells and activated T cells particularly on those with an effector memory phenotype. Detecting KLRG1 expression often involves flow cytometry techniques using specific anti-KLRG1 antibodies.
Biological function summary

KLRG1 serves as a modulator of immune responses by delivering inhibitory signals that regulate immune cell cytotoxicity and cytokine production. It is not part of a larger protein complex but interacts with other molecules on the cell surface to perform its role. The engagement of its ligands mediates the reduction of immune responses which is important during chronic infections and cancer to prevent excessive immune activation.

Pathways

Several immune regulatory pathways involve KLRG1. It notably participates in the balance between immune activation and inhibition within the immune system. KLRG1 interacts with signaling pathways such as those regulated by T-cell receptor (TCR) signaling and NK cell activation. Related proteins in these pathways include CD226 and NKG2A which also play a role in determining the immune cell response.

KLRG1 has relevance in chronic infections and cancer due to its role in regulating immune cell activity. In chronic viral infections such as HIV and hepatitis KLRG1 expression is upregulated coinciding with T cell exhaustion. This marker is also significant in cancer where it contributes to the immune evasion mechanisms of tumors. The association with other proteins like PD-1 and TIM-3 further highlights KLRG1's function in these contexts serving as potential targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Klrg1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 16:867-883 PubMed37915320

2023

B7 Induces Apoptosis in Colorectal Cancer Cells by Regulating the Expression of Caspase-3 and Inhibits Autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyi Zhang,Fengxi Li,Rong Li,Nan Zhao,Dianfeng Liu,Yuelin Xu,Lei Wang,Dongxu Wang,Ruihong Zhao
View all publications
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