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AB30680

Anti-VIP antibody [02]

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(7 Publications)

Mouse Monoclonal VIP antibody. Suitable for ELISA, IHC-P and reacts with Rat, Pig, Human, Cow samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human VIP.

View Alternative Names

VIP peptides, VIP

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human appendix tissue labelling VIP with ab30680 at a dilution of 1/100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreas tissue labelling VIP with ab30680 at a dilution of 1/100. Signal is strong in the nerves of the exocrine part of the pancreas.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreas tissue labelling VIP with ab30680 at a dilution of 1/100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP antibody [02] (AB30680)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human appendix tissue labelling VIP with ab30680 at a dilution of 1/100.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

02

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Human, Rat, Pig, Cow

Applications

ELISA, IHC-P

applications

Immunogen

Synthetic Peptide within Human VIP. The exact immunogen used to generate this antibody is proprietary information.

P01282

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>This dilution applies to VIP coated directly at 2 ug/mL. For glutaraldehyde linked VIP ovalbumin (molar ratio 4:1) coated at 2 ug/mL, the dilution is 1/32,000.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>This dilution applies to VIP coated directly at 2 ug/mL. For glutaraldehyde linked VIP ovalbumin (molar ratio 4:1) coated at 2 ug/mL, the dilution is 1/32,000.</p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>This dilution applies to VIP coated directly at 2 ug/mL. For glutaraldehyde linked VIP ovalbumin (molar ratio 4:1) coated at 2 ug/mL, the dilution is 1/32,000.</p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>This dilution applies to VIP coated directly at 2 ug/mL. For glutaraldehyde linked VIP ovalbumin (molar ratio 4:1) coated at 2 ug/mL, the dilution is 1/32,000.</p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

Fusion partner: SP2mIL6.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Vasoactive Intestinal Peptide (VIP) also known as VIP or Alexa VIP is a 28-amino acid neuropeptide with a molecular mass of approximately 3326 Da. VIP is broadly expressed in both the central and peripheral nervous systems. It plays a mechanical role as a neurotransmitter and neuromodulator impacting various physiological functions such as vasodilation regulation of prolactin secretion and modulation of intestinal motility. By engaging in these processes VIP affects multiple bodily systems and acts at many sites within the human body.
Biological function summary

This protein influences immune response smooth muscle activity and circadian rhythm. VIP operates independently and as part of a complex in the body interacting with specific receptor types on the cellular surface like VPAC1 and VPAC2 receptors which are part of the G-protein coupled receptors family. VIP’s role as a regulator of immune response includes modulation of cytokine production and influencing lymphocyte activity implicating it as a significant player in homeostasis.

Pathways

A well-known function of VIP involves its participation in the cAMP signaling pathway which contributes to various cellular responses like neurotransmitter release and neuropeptide-mediated pathways influencing endocrine systems. VIP's activity in these pathways connects it to other proteins such as adenylate cyclase which it influences to increase cAMP levels further affecting processes such as synaptic transmission and the regulation of circadian rhythms. Through these pathways VIP affects physiological processes across the nervous and endocrine systems coordinating different aspects of bodily function.

VIP has notable associations with conditions such as inflammatory bowel disease (IBD) and asthma. The modulation of inflammatory processes by VIP impacts these diseases by influencing immune responses which can either exacerbate or alleviate symptoms. In IBD VIP interacts with elements of the immune system reducing inflammation and helping maintain mucosal integrity. In asthma VIP can alter airway inflammation and smooth muscle contraction through its pathways connected to the immune system and smooth muscle tissues interacting with proteins like cytokines that play roles in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Vasoactive intestinal peptide. VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors : VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed : 1318039, PubMed : 36385145, PubMed : 8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed : 3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed : 15013843).. Intestinal peptide PHM-27. Bioactive forms that cause vasodilation (PubMed : 15013843, PubMed : 3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed : 15013843).. Intestinal peptide PHV-42. Bioactive forms that cause vasodilation (PubMed : 15013843, PubMed : 3654650).
See full target information VIP
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:21174 PubMed39256434

2024

Giant pyramidal neurons of the primary motor cortex express vasoactive intestinal polypeptide (VIP), a known marker of cortical interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Sadaf Teymornejad,Katrina H Worthy,Marcello G P Rosa,Nafiseh Atapour

Frontiers in microbiology 14:1274559 PubMed38163069

2024

Therapeutic effects of curcumin on constipation-predominant irritable bowel syndrome is associated with modulating gut microbiota and neurotransmitters.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoting Tu,Hongyan Ren,Shurui Bu

Molecular and cellular biochemistry 478:2779-2787 PubMed36920577

2023

Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells.

Applications

Unspecified application

Species

Unspecified reactive species

Filipa P Ferreira,Sofia S Pereira,Madalena M Costa,Marta Guimarães,Nicolai J Wewer Albrechtsen,Jens J Holst,Mário Nora,Mariana P Monteiro

The Journal of veterinary medical science 85:123-134 PubMed36517005

2022

Histological study on regional specificity of the mucosal nerve network in the rat large intestine.

Applications

Unspecified application

Species

Unspecified reactive species

Satoki Nakanishi,Youhei Mantani,Nobuhiko Ohno,Rinako Morishita,Toshifumi Yokoyama,Nobuhiko Hoshi

Scientific reports 12:17851 PubMed36284123

2022

An efficient rAAV vector for protein expression in cortical parvalbumin expressing interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana Tkatch,Kristina Rysevaite-Kyguoliene,Ignas Sabeckis,Deimante Sabeckiene,Dainius H Pauza,Gytis Baranauskas

Cell reports 35:109033 PubMed33910011

2021

An orbitofrontal cortex to midbrain projection modulates hypersensitivity after peripheral nerve injury.

Applications

Unspecified application

Species

Unspecified reactive species

Junting Huang,Zizhen Zhang,Eder Gambeta,Lina Chen,Gerald W Zamponi

Frontiers in neuroscience 14:635 PubMed32733184

2020

Is Ross Syndrome a New Type of Synucleinopathy? A Brief Research Report.

Applications

Unspecified application

Species

Unspecified reactive species

Mingming Ma,Jing Yao,Yongkang Chen,Han Liu,Danhao Xia,Haiyan Tian,Xinxin Wang,Erxi Wu,Xuejing Wang,Xuebing Ding
View all publications
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Product promise

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