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Rabbit Polyclonal VIP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 aa 850-1000.


Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP2 antibody (AB204374), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-VIP2 antibody (AB204374), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 aa 850-1000. The exact immunogen used to generate this antibody is proprietary information. Database link O43314

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC/IF
Human
Tested
Tested
Orangutan
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/1000.00000 - 1/2500.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species

Orangutan

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

0.25000-2.00000 µg/mL

Notes

-

Predicted
Predicted

Species

Orangutan

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114).

Alternative names

Recommended products

Rabbit Polyclonal VIP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 aa 850-1000.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 aa 850-1000. The exact immunogen used to generate this antibody is proprietary information. Database link O43314
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The vasointestinal peptide receptor type 2 (VIP2) also known as VIPR2 is a transmembrane G protein-coupled receptor with a mass of approximately 52 kDa. VIP2 mediates its effects through the binding of vasoactive intestinal peptide (VIP). It predominantly expresses in the central nervous system including the hippocampus and cerebral cortex and some peripheral tissues such as the gastrointestinal tract. VIPR2 plays an important role in transmitting extracellular signals into intracellular responses.

Biological function summary

Within different tissues VIP2 functions in regulating circadian rhythms immune responses and neuroprotection. VIP2 serves as an important component of a receptor complex that interacts with other neuropeptides and neurotransmitters. Its activity influences the modulation of neurophysiological processes such as neurotransmission and hormone secretion. The receptor's ability to initiate cAMP production following VIP binding is central to its biological activity.

Pathways

VIP2 is involved in critical signaling pathways like the cAMP-PKA signaling pathway and the circadian rhythm regulation pathway. These pathways allow the integration of environmental signals to maintain homeostasis and organism health. In the cAMP-PKA pathway VIP2 interacts closely with related receptors such as VPAC1 and VPAC2 sharing similar downstream effects that ultimately impact gene expression and cellular communication.

Associated diseases and disorders

VIP2 has been associated with schizotypal personality disorder and certain autoimmune conditions. There is evidence suggesting VIP2 variations may contribute to altered neurodevelopment processes linked to psychiatric conditions. The receptor's dysfunction impacts neuroinflammation where it might connect with proteins like cytokines and chemokines that mediate immune responses. Understanding VIP2's role could lead to potential therapeutic targets for these challenging conditions.

Product promise

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP2 antibody (ab204374), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VIP2 antibody (ab204374)

    Immunohistochemical analysis of Human paraffin-embedded hippocampus tissue labeling VIP2 with ab204374 at 1/1000 dilution.

  • Immunocytochemistry/ Immunofluorescence - Anti-VIP2 antibody (ab204374), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-VIP2 antibody (ab204374)

    Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2OS cells labeling VIP2 with ab204374 at 4 μg/ml (green).

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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