Rabbit Polyclonal VIP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 aa 850-1000.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Orangutan | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Orangutan | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Orangutan | Dilution info - | Notes - |
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Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114).
HISPPD1, KIAA0433, VIP2, PPIP5K2, HISPPD1, KIAA0433, VIP2, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, Diphosphoinositol pentakisphosphate kinase 2, Histidine acid phosphatase domain-containing protein 1, InsP6 and PP-IP5 kinase 2, VIP1 homolog 2, hsVIP2
Rabbit Polyclonal VIP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 aa 850-1000.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The vasointestinal peptide receptor type 2 (VIP2) also known as VIPR2 is a transmembrane G protein-coupled receptor with a mass of approximately 52 kDa. VIP2 mediates its effects through the binding of vasoactive intestinal peptide (VIP). It predominantly expresses in the central nervous system including the hippocampus and cerebral cortex and some peripheral tissues such as the gastrointestinal tract. VIPR2 plays an important role in transmitting extracellular signals into intracellular responses.
Within different tissues VIP2 functions in regulating circadian rhythms immune responses and neuroprotection. VIP2 serves as an important component of a receptor complex that interacts with other neuropeptides and neurotransmitters. Its activity influences the modulation of neurophysiological processes such as neurotransmission and hormone secretion. The receptor's ability to initiate cAMP production following VIP binding is central to its biological activity.
VIP2 is involved in critical signaling pathways like the cAMP-PKA signaling pathway and the circadian rhythm regulation pathway. These pathways allow the integration of environmental signals to maintain homeostasis and organism health. In the cAMP-PKA pathway VIP2 interacts closely with related receptors such as VPAC1 and VPAC2 sharing similar downstream effects that ultimately impact gene expression and cellular communication.
VIP2 has been associated with schizotypal personality disorder and certain autoimmune conditions. There is evidence suggesting VIP2 variations may contribute to altered neurodevelopment processes linked to psychiatric conditions. The receptor's dysfunction impacts neuroinflammation where it might connect with proteins like cytokines and chemokines that mediate immune responses. Understanding VIP2's role could lead to potential therapeutic targets for these challenging conditions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunohistochemical analysis of Human paraffin-embedded hippocampus tissue labeling VIP2 with ab204374 at 1/1000 dilution.
Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2OS cells labeling VIP2 with ab204374 at 4 μg/ml (green).
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