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AB67000

Anti-VIP36 antibody [264C4a]

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(1 Publication)

Mouse Monoclonal VIP36 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LMAN2.

View Alternative Names

C5orf8, LMAN2, Vesicular integral-membrane protein VIP36, Glycoprotein GP36b, Lectin mannose-binding 2, Vesicular integral-membrane protein 36, VIP36

1 Images
Western blot - Anti-VIP36 antibody [264C4a] (AB67000)
  • WB

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Western blot - Anti-VIP36 antibody [264C4a] (AB67000)

All lanes:

Western blot - Anti-VIP36 antibody [264C4a] (ab67000)

All lanes:

immunogen

Predicted band size: 40 kDa

Observed band size: 35 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

264C4a

Isotype

IgG2a

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LMAN2. The exact immunogen used to generate this antibody is proprietary information.

Q12907

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

VIP36 also known as vesicular integral-membrane protein 36 operates as a lectin involved in glycoprotein transport within the cell. It has a mass of approximately 36 kDa. Scientists observe its expression mainly in the liver and testis where it localizes to the Golgi apparatus and endoplasmic reticulum. VIP36 functions to select specific N-linked glycans facilitating their sorting and transport essential for proper protein localization and function.
Biological function summary

Vesicular integral-membrane protein 36 contributes to the quality control of glycoproteins within the secretory pathway. While not forming part of a larger complex VIP36 plays a critical role in recognizing high-mannose-type glycoproteins which are critical for cell-cell communication and adhesion. This function helps maintain cellular homeostasis and impacts various cellular activities reflecting the protein's importance in cellular processes.

Pathways

Glycoprotein transport and sorting rely on VIP36 which interacts with pathways like the secretory pathway and vesicle trafficking. The protein impacts the dynamics of protein glycosylation fundamental for the correct functioning of proteins like E-cadherin. By ensuring glycoproteins reach their proper destinations within the cell VIP36 plays an important role in maintaining cellular architecture and facilitating important signaling processes.

Disruptions in VIP36 functionality might contribute to disorders like liver cirrhosis and testicular malfunction. Problems in its glycoprotein sorting capability can affect proteins such as alpha-fetoprotein potentially altering normal cellular function and leading to disease. Researchers continue to investigate VIP36's role in these disorders aiming to understand how alterations in this protein could offer insights into therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).
See full target information LMAN2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of proteomics 74:1994-2007 PubMed21635978

2011

Identification and validation of six proteins as marker for endemic nephropathy.

Applications

WB

Species

Human

Ivana Pešić,Vladisav Stefanović,Gerhard A Müller,Claudia A Müller,Rade Cukuranović,Olaf Jahn,Vladmila Bojanić,Michael Koziolek,Hassan Dihazi
View all publications
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