AB208286
Rabbit Polyclonal Viperin antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RSAD2 aa 100-350.
1 Images
- WB
Supplier Data
Western blot - Anti-Viperin antibody (AB208286)
All lanes:
Western blot - Anti-Viperin antibody (ab208286) at 3 µg/mL
All lanes:
Human brain lysate
Predicted band size: 42 kDa
false
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Reactivity data
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Properties and storage information
Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
Product protocols
For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data
Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon (PubMed : 31812350). Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism (PubMed : 29925952, PubMed : 30872404). In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication (PubMed : 29925952). Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1) (PubMed : 29925952, PubMed : 30587778, PubMed : 30934824, PubMed : 31921110). Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6 (PubMed : 30872404). Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
Alternative Names
CIG5, RSAD2, S-adenosylmethionine-dependent nucleotide dehydratase RSAD2, SAND, Cytomegalovirus-induced gene 5 protein, Radical S-adenosyl methionine domain-containing protein 2, Viperin
Publications (2)
Recent publications for all applications. Explore the full listand refine your search
The Journal of biological chemistry 300:107783 PubMed39303913
2024
Downregulation of the mA reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members.
Applications
Unspecified application
Species
Unspecified reactive species
Zhixin Yin,Lifang Ma,Xiaoting Tian,Qi Sun,Congcong Zhang,Yikun Wang,Yayou Miao,Xiangfei Xue,Yongjie Wang,Jiayi Wang,Xiao Zhang,Xumin Hou
Genome biology 24:17 PubMed36694229
2023
The mechanism underlying redundant functions of the YTHDF proteins.
Applications
Unspecified application
Species
Unspecified reactive species
Zhongyu Zou,Caraline Sepich-Poore,Xiaoming Zhou,Jiangbo Wei,Chuan He
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