Rabbit Polyclonal Vitamin D Receptor phospho S208 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human VDR phospho S208.
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Publications
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- The Journal of experimental medicine 207:731-502010Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia.Applications:WBReactive species:HumanCeline Callens,Séverine Coulon,Jerome Naudin,Isabelle Radford-Weiss,Nicolas Boissel,Emmanuel Raffoux,Pamella Huey Mei Wang,Saurabh Agarwal,Houda Tamouza,Etienne Paubelle,Vahid Asnafi,Jean-Antoine Ribeil,Philippe Dessen,Danielle Canioni,Olivia Chandesris,Marie Therese Rubio,Carole Beaumont,Marc Benhamou,Hervé Dombret,Elizabeth Macintyre,Renato C Monteiro,Ivan C Moura,Olivier HerminePubMed 20368581
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human VDR phospho S208. The exact immunogen used to generate this antibody is proprietary information. Database link P11473
Reactivity data
Select an application| ICC/IF | |
|---|---|
| Human | Tested |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
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Target data
Function
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638).
Alternative names
NR1I1, VDR, Vitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1
Recommended products
Rabbit Polyclonal Vitamin D Receptor phospho S208 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human VDR phospho S208.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human VDR phospho S208. The exact immunogen used to generate this antibody is proprietary information. Database link P11473
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
Purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunocytochemistry/ Immunofluorescence - Anti-Vitamin D Receptor (phospho S208) antibody (ab63572)
Immunofluorescent staining of A549 cells, using ab63572 at a 1/500 dilution, minus immunising peptide (left image) and plus immunising peptide (right image).
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