AB70808

Anti-VMAT2 antibody

Name: Anti-VMAT2 antibody (ab70808) | Abcam
Brand: Abcam Limited
SKU: AB70808
Price: 505 USD
Availability: InStock
Rating: 1 (1 reviews)

(1 Review)

(12 Publications)

Rabbit Polyclonal VMAT2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human SLC18A2.

View Alternative Names

SVMT, VMAT2, SLC18A2, Synaptic vesicular amine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, Vesicular monoamine transporter 2, VAT2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human SLC18A2. The exact immunogen used to generate this antibody is proprietary information.

Q05940

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The vesicular monoamine transporter 2 (VMAT2) also known as SLC18A2 is a protein that is important for transporting neurotransmitters like dopamine serotonin norepinephrine and histamine into synaptic vesicles. VMAT2 has a mass of approximately 70 kDa and is mainly found in the brain where it is expressed in neurons. Its activity relies on the proton gradient across the vesicular membrane enabling it to concentrate neurotransmitters in vesicles for release into the synaptic cleft.

Biological function summary

VMAT2 handles the packaging and storage of important monoamine neurotransmitters which play a role in mood regulation cognition and movement. Although VMAT2 acts independently it is important for the functioning of neurotransmitter transport and release. By storing neurotransmitters into vesicles VMAT2 ensures that neurons can quickly release them into the synapse when needed supporting efficient neural signaling.

Pathways

VMAT2 plays an important role in the dopamine and serotonin systems. In the dopamine pathway VMAT2 stores dopamine into vesicles which are then released during neurotransmission. It works closely with the dopamine transporter DAT which reuptakes dopamine from the synaptic cleft back into neurons. Similarly in the serotonin pathway VMAT2 collaborates with the serotonin transporter SERT. These relationships emphasize VMAT2's central position in modulating neurotransmitter signaling linking it to mood and motor control regulation.

VMAT2 has a notable link to neurological and psychiatric conditions. Parkinson's disease characterized by the loss of dopaminergic neurons shows disrupted VMAT2 function affecting dopamine storage and release. In depression altered monoamine neurotransmitter levels including serotonin and dopamine involve VMAT2 dysfunction. The protein is not only connected to these diseases through its own function but also through its interactions with DAT and SERT which are key players in these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed : 23363473, PubMed : 37914936, PubMed : 38081299, PubMed : 38517752, PubMed : 8643547). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed : 8860238).

See full target information SLC18A2

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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

The European journal of neuroscience 59:2465-2482 PubMed38487941

2024

Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content.

Applications

Unspecified application

Species

Unspecified reactive species

Sherilyn Junelle Recinto,Shobina Premachandran,Sriparna Mukherjee,Alexis Allot,Adam MacDonald,Moein Yaqubi,Samantha Gruenheid,Louis-Eric Trudeau,Jo Anne Stratton

Annals of translational medicine 10:1314 PubMed36660708

2023

Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson's disease rats.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofan Wang,Tong Su,Lifei Xiao,Yangyang Wang,Xianhao Huo,Wenchao Li,Jiangwei Ding,Tao Sun

International journal of molecular sciences 23: PubMed36499749

2022

Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females.

Applications

Unspecified application

Species

Unspecified reactive species

Marta Pardo,Michele Martin,Raul R Gainetdinov,Deborah C Mash,Sari Izenwasser

Antioxidants (Basel, Switzerland) 11: PubMed36358479

2022

O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson's Disease Mouse Models.

Applications

Unspecified application

Species

Unspecified reactive species

Hyeon Jin Lee,Kyonghwan Choe,Jun Sung Park,Amjad Khan,Min Woo Kim,Tae Ju Park,Myeong Ok Kim

Aging 12:3042-3052 PubMed32074509

2020

Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Chen,Tianlan Lan,Yue Wang,Yong He,Zhonghao Wu,Yu Tian,Yan Li,Mengge Bai,Wei Zhou,Hanping Zhang,Ke Cheng,Peng Xie

Cell reports 29:4646-4656.e4 PubMed31875567

2019

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Angelo Iannielli,Giovanni Stefano Ugolini,Chiara Cordiglieri,Simone Bido,Alicia Rubio,Gaia Colasante,Marco Valtorta,Tommaso Cabassi,Marco Rasponi,Vania Broccoli

The Journal of comparative neurology 528:935-952 PubMed31674014

2019

Distribution of tyrosine-hydroxylase-immunoreactive neurons in the hypothalamus of tree shrews.

Applications

Unspecified application

Species

Unspecified reactive species

Zhao-Huan Huang,Rong-Jun Ni,Peng-Hao Luo,Jiang-Ning Zhou

Molecular brain 12:11 PubMed30736828

2019

Baicalin regulates the dopamine system to control the core symptoms of ADHD.

Applications

Unspecified application

Species

Unspecified reactive species

Rongyi Zhou,Jiaojiao Wang,Xinmin Han,Bingxiang Ma,Haixia Yuan,Yuchen Song

Journal of neurochemistry 149:799-810 PubMed30520040

2019

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Xu,Yong He,Xi Chen,Yu Tian,Ke Cheng,Lu Zhang,Yue Wang,Deyu Yang,Haiyang Wang,Zhonghao Wu,Yan Li,Tianlan Lan,Zhifang Dong,Peng Xie

Evidence-based complementary and alternative medic 2017:2695903 PubMed28293263

2017

Saikosaponin A Alleviates Symptoms of Attention Deficit Hyperactivity Disorder through Downregulation of DAT and Enhancing BDNF Expression in Spontaneous Hypertensive Rats.

Applications

Species

Unspecified reactive species

Sun Jichao,Han Xinmin,Ren Xianguo,Yin Dongqi,Zhou Rongyi,Lei Shuang,You Yue,Song Yuchen,Ying Jingnan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-VMAT2 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (12)

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