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AB224671

Anti-VPS39 antibody

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(3 Publications)

Rabbit Polyclonal VPS39 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VPS39 aa 250-500.

View Alternative Names

KIAA0770, TLP, VAM6, VPS39, Vam6/Vps39-like protein, TRAP1-like protein, hVam6p

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-VPS39 antibody (AB224671)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-VPS39 antibody (AB224671)

A549 (human lung carcinoma cell line) cells stained for VPS39 (green) using ab224671 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VPS39 antibody (AB224671)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VPS39 antibody (AB224671)

Paraffin-embedded human liver cancer tissue stained for VPS39 using ab224671 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human VPS39 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.

Q96JC1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed : 23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed : 11448994, PubMed : 23167963, PubMed : 23351085). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed : 25783203, PubMed : 37821429).
See full target information VPS39
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Brain communications 7:fcaf182 PubMed40462859

2025

Intra-amniotic infection with causes serovar-dependent white matter damage in preterm fetal sheep.

Applications

Unspecified application

Species

Unspecified reactive species

Dima Abdu,Graeme R Polglase,Sharmony B Kelly,Sinead Murphy,Ilias Nitsos,Claudia A Nold-Petry,Suhas G Kallapur,Alan H Jobe,John P Newnham,Timothy J Moss,Robert Galinsky

Acta neuropathologica 142:807-825 PubMed34453582

2021

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zhao,Wenyan Lu,Yingxue Ren,Yuan Fu,Yuka A Martens,Francis Shue,Mary D Davis,Xue Wang,Kai Chen,Fuyao Li,Chia-Chen Liu,Neill R Graff-Radford,Zbigniew K Wszolek,Steven G Younkin,David A Brafman,Nilüfer Ertekin-Taner,Yan W Asmann,Dennis W Dickson,Ziying Xu,Meixia Pan,Xianlin Han,Takahisa Kanekiyo,Guojun Bu

Science immunology 6: PubMed34145066

2021

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Jin,Chulwoo Kim,Qiong Xia,Timothy M Gould,Wenqiang Cao,Huimin Zhang,Xuanying Li,Daniela Weiskopf,Alba Grifoni,Alessandro Sette,Cornelia M Weyand,Jorg J Goronzy
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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