AB231030

Anti-Warp antibody

Name: Anti-Warp antibody (ab231030) | Abcam
Brand: Abcam Limited
SKU: AB231030

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(1 Publication)

Rabbit Polyclonal Warp antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human von Willebrand factor A domain-containing protein 1 aa 1-300.

View Alternative Names

von Willebrand factor A domain-containing protein 1, VWA1

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Formalin-fixed, paraffin-embedded human liver tissue stained for Warp with ab231030 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Formalin-fixed, paraffin-embedded human skin cancer tissue stained for Warp with ab231030 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for Warp with ab231030 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Formalin-fixed, paraffin-embedded human stomach tissue stained for Warp with ab231030 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Warp antibody (AB231030)

All lanes:

Western blot - Anti-Warp antibody (ab231030) at 2 µg/mL

All lanes:

Recombinant human Warp protein

Secondary

All lanes:

HRP-linked Guinea Pig Anti-Rabbit at 1/1000 dilution

Predicted band size: 47 kDa,72 kDa,87 kDa

false

Supplier Data

Western blot - Anti-Warp antibody (AB231030)

All lanes:

Western blot - Anti-Warp antibody (ab231030) at 2 µg/mL

All lanes:

Rat testis tissue lysate

Secondary

All lanes:

HRP-linked Guinea Pig Anti-Rabbit at 1/1000 dilution

Predicted band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human von Willebrand factor A domain-containing protein 1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q6PCB0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Warp also known as Wind and Recovery Protein plays a role in cytoskeletal arrangement and cellular architecture. This protein has an approximate molecular mass of 55 kDa and is highly expressed in neuronal tissues particularly in areas of the brain responsible for signal transmission. Warp associates with microtubules aiding in their stabilization and dynamics. It has a signature sequence that interacts with tubulin contributing to its regulatory functions within the cell.

Biological function summary

Warp interacts with cytoskeletal networks to maintain cellular structure and support cellular transport. It becomes part of a larger protein complex that facilitates microtubule assembly. The protein plays a significant role in neuronal cells supporting axonal transport which is essential for nerve function. Warp's involvement in maintaining dynamic microtubules suggests its potential influence on cellular processes that require robust structural integrity and adaptability.

Pathways

Warp is integral to the MAPK signaling pathway and is an important player in intracellular transport operations. By participating in this pathway Warp influences cellular reactions to external stimuli. It also interfaces with proteins such as MAPK and kinesin which are critical to signal transduction and movement along microtubules respectively. These interactions help modulate cellular responses and maintain efficient cellular trafficking.

Research highlights Warp's role in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. Dysfunction in Warp's regulation of the cytoskeleton can lead to impaired axonal transport contributing to neuronal degeneration seen in these disorders. The protein has a connection with tau a protein implicated in the aggregation seen in Alzheimer's pathology. Disruptions in Warp-tubulin interactions can exacerbate the progression of these neurodegenerative diseases pointing to the potential of Warp as a target for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Promotes matrix assembly (By similarity). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (Probable).

See full target information von Willebrand factor A domain-containing protein 1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 135: PubMed40166934

2025

Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Shike Wang,Houfu Guo,Reo Fukushima,Masahiko Terajima,Min Liu,Guan-Yu Xiao,Lenka Koudelková,Chao Wu,Xin Liu,Jiang Yu,Emma Burris,Jun Xu,Alvise Schiavinato,William K Russell,Mitsuo Yamauchi,Xiaochao Tan,Jonathan M Kurie

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Warp antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Warp antibody (AB231030)

Western blot - Anti-Warp antibody (AB231030)

Western blot - Anti-Warp antibody (AB231030)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise