Anti-Warp antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Warp also known as Wind and Recovery Protein plays a role in cytoskeletal arrangement and cellular architecture. This protein has an approximate molecular mass of 55 kDa and is highly expressed in neuronal tissues particularly in areas of the brain responsible for signal transmission. Warp associates with microtubules aiding in their stabilization and dynamics. It has a signature sequence that interacts with tubulin contributing to its regulatory functions within the cell.

Biological function summary

Warp interacts with cytoskeletal networks to maintain cellular structure and support cellular transport. It becomes part of a larger protein complex that facilitates microtubule assembly. The protein plays a significant role in neuronal cells supporting axonal transport which is essential for nerve function. Warp's involvement in maintaining dynamic microtubules suggests its potential influence on cellular processes that require robust structural integrity and adaptability.

Pathways

Warp is integral to the MAPK signaling pathway and is an important player in intracellular transport operations. By participating in this pathway Warp influences cellular reactions to external stimuli. It also interfaces with proteins such as MAPK and kinesin which are critical to signal transduction and movement along microtubules respectively. These interactions help modulate cellular responses and maintain efficient cellular trafficking.

Associated diseases and disorders

Research highlights Warp's role in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. Dysfunction in Warp's regulation of the cytoskeleton can lead to impaired axonal transport contributing to neuronal degeneration seen in these disorders. The protein has a connection with tau a protein implicated in the aggregation seen in Alzheimer's pathology. Disruptions in Warp-tubulin interactions can exacerbate the progression of these neurodegenerative diseases pointing to the potential of Warp as a target for therapeutic intervention.