Anti-WDR18 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

WDR18 also known as WD repeat domain 18 is a protein that plays a role in cellular assembly processes. It has a mass of approximately 58 kDa and is found in several tissues including the brain and liver. WDR18 interacts with proteins containing WD repeats and functions as a scaffold for multiprotein complex assembly. This scaffolding role is essential in managing protein interactions necessary for cellular structure and movement.

Biological function summary

WDR18 functions within ribonucleoprotein complexes that are important for ribosome biogenesis. It acts in coordination with proteins like NOP58 and NCL within the nucleolus an important site for ribosome synthesis. These complexes support the correct processing of ribosomal RNA which is critical for cell growth and proliferation. WDR18 contributes to maintaining cellular protein synthesis ensuring effective cellular division and function.

Pathways

WDR18 participates in ribosome biogenesis and assembly pathways. It works alongside proteins within the mTOR signaling pathway which modulates cell growth and metabolism. In these pathways WDR18 supports interactions with other key proteins such as S6K1 and eIF4E ensuring accurate translation and cellular homeostasis. This integration into essential cellular pathways underlies its importance in managing cell growth and protein production.

Associated diseases and disorders

WDR18 is associated with certain cancers and developmental disorders. In particular abnormalities in WDR18 expression can correlate with tumorigenesis in cancers like liver cancer. Connections with proteins such as MYC highlight its role in cancerous cell proliferation. Also mutations in WDR18 have been related to developmental issues affecting neural and physical development demonstrating its involvement in maintaining healthy cellular and organismal development.