JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB176261

Anti-WDR18 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal WDR18 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human WDR18.

View Alternative Names

WD repeat-containing protein 18, WDR18

1 Images
Western blot - Anti-WDR18 antibody (AB176261)
  • WB

Supplier Data

Western blot - Anti-WDR18 antibody (AB176261)

Lane 1:

Western blot - Anti-WDR18 antibody (ab176261) at 0.5 µg/mL

Lane 2:

Western blot - Anti-WDR18 antibody (ab176261) at 1 µg/mL

All lanes:

Rat lung tissue lysate at 15 µg

Predicted band size: 47 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human WDR18. The exact immunogen used to generate this antibody is proprietary information.

Q9BV38

Specificity

ab176261 is predicted to not cross-react with other WDR family members.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR18 also known as WD repeat domain 18 is a protein that plays a role in cellular assembly processes. It has a mass of approximately 58 kDa and is found in several tissues including the brain and liver. WDR18 interacts with proteins containing WD repeats and functions as a scaffold for multiprotein complex assembly. This scaffolding role is essential in managing protein interactions necessary for cellular structure and movement.
Biological function summary

WDR18 functions within ribonucleoprotein complexes that are important for ribosome biogenesis. It acts in coordination with proteins like NOP58 and NCL within the nucleolus an important site for ribosome synthesis. These complexes support the correct processing of ribosomal RNA which is critical for cell growth and proliferation. WDR18 contributes to maintaining cellular protein synthesis ensuring effective cellular division and function.

Pathways

WDR18 participates in ribosome biogenesis and assembly pathways. It works alongside proteins within the mTOR signaling pathway which modulates cell growth and metabolism. In these pathways WDR18 supports interactions with other key proteins such as S6K1 and eIF4E ensuring accurate translation and cellular homeostasis. This integration into essential cellular pathways underlies its importance in managing cell growth and protein production.

WDR18 is associated with certain cancers and developmental disorders. In particular abnormalities in WDR18 expression can correlate with tumorigenesis in cancers like liver cancer. Connections with proteins such as MYC highlight its role in cancerous cell proliferation. Also mutations in WDR18 have been related to developmental issues affecting neural and physical development demonstrating its involvement in maintaining healthy cellular and organismal development.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed : 22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed : 21326211). May play a role during development (By similarity).
See full target information WDR18
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nutrition & metabolism 19:17 PubMed35248109

2022

The combination of endurance exercise and SGTC (Salvia-Ginseng-Trigonella-Cinnamon) ameliorate mitochondrial markers' overexpression with sufficient ATP production in the skeletal muscle of mice fed AGEs-rich high-fat diet.

Applications

Unspecified application

Species

Unspecified reactive species

Maryam Haghparast Azad,Iman Niktab,Shaghayegh Dastjerdi,Navid Abedpoor,Golbarg Rahimi,Zahra Safaeinejad,Maryam Peymani,Farzad Seyed Forootan,Majid Asadi-Shekaari,Mohammad Hossein Nasr Esfahani,Kamran Ghaedi
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB154190

Anti-WDR77 antibody [EPR10708(B)]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR77 antibody [EPR10708(B)] (AB154190)

  • 5
  • 2
Primary Antibodies

AB176817

Anti-WDR3 antibody

Western blot - Anti-WDR3 antibody (AB176817)

  • 0
  • 0
Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0
Primary Antibodies

AB200376

Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com