AB105044

Anti-WDR19 antibody

Name: Anti-WDR19 antibody (ab105044) | Abcam
Brand: Abcam Limited
SKU: AB105044

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(1 Publication)

Rabbit Polyclonal WDR19 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human WDR19 aa 50-300.

View Alternative Names

IFT144, KIAA1638, WDR19, WD repeat-containing protein 19, Intraflagellar transport 144 homolog

1 Images

Unknown

Western blot - Anti-WDR19 antibody (AB105044)

5% SDS PAGE

All lanes:

Western blot - Anti-WDR19 antibody (ab105044) at 1/1000 dilution

All lanes:

Mouse brain whole cell lysate at 50 µg

Predicted band size: 145 kDa,151 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human WDR19 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q8NEZ3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR19 also known as WD repeat-containing protein 19 or IFT144 plays an essential mechanical role in the intraflagellar transport system. This protein with a molecular mass of approximately 109 kDa facilitates movement of molecular cargo along axonemes within cilia. WDR19 expresses in ciliated cells across various tissues and contributes to ciliogenesis and maintenance of normal ciliary function. Its primary role involves interactions with other intraflagellar transport proteins aiding transportation processes within cilia.

Biological function summary

This protein contributes to the structure and function of motile and sensory cilian important components in cell signaling and motility. WDR19 operates as part of the IFT-A complex consisting of six proteins. These complexes help regulate the anterograde and retrograde transport essential for maintaining ciliary integrity. The precise interaction among IFT-A proteins allows efficient delivery and recycling of ciliary components thereby supporting cellular processes like developmental signaling and sensory perception.

Pathways

WDR19 participates extensively in the Hedgehog signaling pathway and the Wnt signaling pathway both important for development and differentiation. In Hedgehog signaling effective ciliary transport facilitated by WDR19 regulates the movement of morphogens necessary for patterning tissues during embryogenesis. Additionally its role in Wnt pathways helps modulate processes like cell fate determination. Within these pathways proteins such as IFT27 and IFT88 cooperate with WDR19 ensuring precise transport and signaling activities.

Mutations in WDR19 can lead to ciliopathies including Sensenbrenner syndrome and nephronophthisis. Sensenbrenner syndrome presents with skeletal and craniofacial abnormalities due to disrupted ciliary function while nephronophthisis results in kidney disorders caused by dysfunctional cilia. WDR19 interacts with proteins like WDR35 and NPHP2 in these conditions which further establishes the disruptions in transport activities in ciliopathies. Understanding these interactions helps in identifying potential therapeutic targets to address these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed : 20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed : 20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity).

See full target information WDR19

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 79:103472 PubMed39752998

2025

Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Linlin Zhang,Fangshi Zhao,Yize Li,Zhenhua Song,Lingyue Hu,Yuanjie Li,Rui Zhang,Yonghao Yu,Guolin Wang,Chunyan Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-WDR19 antibody

Western blot - Anti-WDR19 antibody (AB105044)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise