Rabbit Polyclonal WDR19 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human WDR19 aa 1-250.
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
IHC-P | ICC/IF | |
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Human | Tested | Tested |
Species | Dilution info | Notes |
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Species Human | Dilution info 1/20 - 1/200 | Notes - |
Species | Dilution info | Notes |
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Species Human | Dilution info 1/50 - 1/200 | Notes - |
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As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity).
IFT144, KIAA1638, WDR19, WD repeat-containing protein 19, Intraflagellar transport 144 homolog
Rabbit Polyclonal WDR19 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human WDR19 aa 1-250.
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Purity >95%
WDR19 also known as WD repeat-containing protein 19 or IFT144 plays an essential mechanical role in the intraflagellar transport system. This protein with a molecular mass of approximately 109 kDa facilitates movement of molecular cargo along axonemes within cilia. WDR19 expresses in ciliated cells across various tissues and contributes to ciliogenesis and maintenance of normal ciliary function. Its primary role involves interactions with other intraflagellar transport proteins aiding transportation processes within cilia.
This protein contributes to the structure and function of motile and sensory cilian important components in cell signaling and motility. WDR19 operates as part of the IFT-A complex consisting of six proteins. These complexes help regulate the anterograde and retrograde transport essential for maintaining ciliary integrity. The precise interaction among IFT-A proteins allows efficient delivery and recycling of ciliary components thereby supporting cellular processes like developmental signaling and sensory perception.
WDR19 participates extensively in the Hedgehog signaling pathway and the Wnt signaling pathway both important for development and differentiation. In Hedgehog signaling effective ciliary transport facilitated by WDR19 regulates the movement of morphogens necessary for patterning tissues during embryogenesis. Additionally its role in Wnt pathways helps modulate processes like cell fate determination. Within these pathways proteins such as IFT27 and IFT88 cooperate with WDR19 ensuring precise transport and signaling activities.
Mutations in WDR19 can lead to ciliopathies including Sensenbrenner syndrome and nephronophthisis. Sensenbrenner syndrome presents with skeletal and craniofacial abnormalities due to disrupted ciliary function while nephronophthisis results in kidney disorders caused by dysfunctional cilia. WDR19 interacts with proteins like WDR35 and NPHP2 in these conditions which further establishes the disruptions in transport activities in ciliopathies. Understanding these interactions helps in identifying potential therapeutic targets to address these conditions.
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A549 (human lung carcinoma cell line) cells stained for WDR19 (green) using ab222908 at 1/100 dilution in ICC/IF. Secondary: Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).
Paraffin-embedded human liver cancer tissue stained for WDR19 using ab222908 at 1/100 dilution in immunohistochemical analysis.
Paraffin-embedded human placenta tissue stained for WDR19 using ab222908 at 1/100 dilution in immunohistochemical analysis.
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