AB85961

Anti-WDR26 antibody

Name: Anti-WDR26 antibody (ab85961) | Abcam
Brand: Abcam Limited
SKU: AB85961

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(4 Publications)

Rabbit Polyclonal WDR26 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human WDR26 aa 150-200.

View Alternative Names

CDW2, MIP2, PRO0852, WDR26, WD repeat-containing protein 26, CUL4- and DDB1-associated WDR protein 2, Myocardial ischemic preconditioning up-regulated protein 2

1 Images

Unknown

Western blot - Anti-WDR26 antibody (AB85961)

All lanes:

Western blot - Anti-WDR26 antibody (ab85961) at 0.4 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Predicted band size: 72 kDa

Observed band size: 72 kDa

true

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human WDR26 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

Q9H7D7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Medaka fish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Tilapia": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Turkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Affinity purified using an epitope specific to WDR26 immobilized on solid support.

Storage buffer

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR26 also known as WD repeat domain 26 is part of the WD repeat protein family which is important in protein-protein interactions. It weighs roughly 109 kDa. WDR26 expresses in various tissues with significant levels observed in the brain and testis. The protein itself has a molecular architecture enriched with WD repeats which facilitates its involvement in cellular processes by mediating complex formation and signal transduction.

Biological function summary

In the cellular environment WDR26 engages in regulating intracellular signaling pathways. It is a component of the STRIPAK complex which includes several proteins playing roles in synaptic and cellular signaling. The involvement of WDR26 in the STRIPAK complex as a scaffold aids in the correct assembly and localization of the complex impacting cellular processes such as apoptosis and proliferation.

Pathways

WDR26 integrates into key signaling pathways like the MAPK signaling pathway. It interacts with other proteins such as STRN3 and MOB3 to modulate signals that affect gene expression growth and cell differentiation. The MAPK pathway in particular facilitates responses to growth factors stress signals and mitogens illustrating the protein's versatility in signal transduction.

Defects or dysregulation of WDR26 relate to intellectual disabilities and certain neurodevelopmental disorders. Research indicates that changes in WDR26 expression can disturb normal brain development and function often connecting with other proteins like MEK1 which also participates in neurodevelopment. These connections link WDR26 closely to neurological functions and highlight its potential as a target for therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

G-beta-like protein involved in cell signal transduction (PubMed : 15378603, PubMed : 19446606, PubMed : 22065575, PubMed : 23625927, PubMed : 26895380, PubMed : 27098453). Acts as a negative regulator in MAPK signaling pathway (PubMed : 15378603). Functions as a scaffolding protein to promote G beta : gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed : 22065575, PubMed : 23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed : 29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed : 27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed : 26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed : 19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).

See full target information WDR26

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature aging 5:1750-1770 PubMed40903652

2025

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation.

Applications

Unspecified application

Species

Unspecified reactive species

Seda Koyuncu,Yaiza Dominguez-Canterla,Rafael Alis,Nassima Salarzai,Dunja Petrovic,Nuria Flames,David Vilchez

Nature communications 16:6807 PubMed40707439

2025

Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Qingzhou Chen,Pengxiao Sun,Jiaxin Zhou,Tantan Long,An Xiao,Zhuoliang Liu,Shihui Xu,Wenjing Lei,Rui Zhang,Jianwei Tian,Miaomiao Zhou,Zheng Hu,Fengxin Zhu,Jing Nie

Nature communications 11:5156 PubMed33056990

2020

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Napoli,Xiaobo Li,Hayley D Ackerman,Avani A Deshpande,Ivan Barannikov,Marlese A Pisegna,Isabelle Bedrosian,Jürgen Mitsch,Philip Quinlan,Alastair Thompson,Kimal Rajapakshe,Cristian Coarfa,Preethi H Gunaratne,Douglas C Marchion,Anthony M Magliocco,Kenneth Y Tsai,Elsa R Flores

Aging 11:3561-3573 PubMed31152142

2019

Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wu,Zijuan Wu,Yi Xia,Shuchao Qin,Yue Li,Jiazhu Wu,Jinhua Liang,Li Wang,Huayuan Zhu,Lei Fan,Jianxin Fu,Wei Xu,Hui Jin,Jianyong Li

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-WDR26 antibody

Western blot - Anti-WDR26 antibody (AB85961)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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