JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB73548

Anti-WDR36 antibody

3

(1 Review)

|

(1 Publication)

Rabbit Polyclonal WDR36 antibody. Suitable for WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human WDR36.

View Alternative Names

WD repeat-containing protein 36, T-cell activation WD repeat-containing protein, TA-WDRP, WDR36

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-Fr, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human WDR36. The exact immunogen used to generate this antibody is proprietary information.

Q8NI36

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR36 also known as WD repeat domain 36 is a protein that weighs approximately 110 kDa. It contains WD repeats suggesting a role in protein-protein interactions. WDR36 is widely expressed in various tissues with notably high levels in retinal cells. Its expression pattern indicates possible involvement in multiple cellular processes especially in the eyes.
Biological function summary

WDR36 acts as a component of the ribosome biogenesis pathway. It forms part of a complex necessary for the processing of 18S ribosomal RNA a critical step in assembling the 40S ribosomal subunit. The function of WDR36 extends to ensuring proper ribosome assembly which is fundamental for protein synthesis in cells.

Pathways

WDR36 has important roles in the ribosome biogenesis and protein synthesis pathways. It interacts with other proteins such as LAS1L and NOL9 both key players in the ribosome assembly process. Through these interactions WDR36 ensures the distribution of ribosomal subunits necessary for translating mRNA into functional proteins.

Mutations in WDR36 have links to primary open-angle glaucoma. This condition leads to progressive optic nerve damage affecting vision. WDR36's interaction with proteins like OPTN hints at a broader role in ocular health possibly influencing cellular stress responses and apoptotic pathways within the eye tissues.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in the nucleolar processing of SSU 18S rRNA (PubMed : 21051332, PubMed : 34516797). Involved in T-cell activation and highly coregulated with IL2 (PubMed : 15177553).
See full target information WDR36
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 20:422-35 PubMed21051332

2010

Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.

Applications

ICC/IF

Species

Human

Martin Gallenberger,Dominik M Meinel,Markus Kroeber,Michael Wegner,Philipp Milkereit,Michael R Bösl,Ernst R Tamm
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB128197

Anti-DDX18 antibody

Immunocytochemistry/ Immunofluorescence - Anti-DDX18 antibody (AB128197)

  • 0
  • 0
Primary Antibodies

AB70462

Anti-DDX24 antibody

Western blot - Anti-DDX24 antibody (AB70462)

  • 4
  • 2
Primary Antibodies

AB76783

Anti-TMEM163 antibody

  • 0
  • 0
Primary Antibodies

AB181074

Anti-DHX8/prp22 antibody [EPR9146(2)]

RabMAb|Recombinant|Trial Size

Western blot - Anti-DHX8/prp22 antibody [EPR9146(2)] (AB181074)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com