Rabbit Polyclonal WDR37 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Wdr37.
View Alternative Names
Kiaa0982, Wdr37, WD repeat-containing protein 37
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)
Paraffin-embedded human colon cancer tissue stained for WDR37 using ab235046 at 1/500 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)
Paraffin-embedded human appendix tissue stained for WDR37 using ab235046 at 1/500 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.
- WB
Supplier Data
Western blot - Anti-WDR37 antibody (AB235046)
All lanes:
Western blot - Anti-WDR37 antibody (ab235046) at 1/500 dilution
All lanes:
HepG2 (human liver hepatocellular carcinoma cell line) cell lysate
Secondary
All lanes:
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55 kDa
false
Reactivity data
Properties and storage information
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Purification notes
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Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
WDR37 participates in cell cycle regulation and signal transduction. It is a part of multiprotein complexes that influence the progression of the cell cycle and mitotic spindle formation. WDR37 aids in organizing the interactions necessary for these cellular activities which contributes to maintaining proper cellular function. It also shows involvement in neurodegenerative processes and has been implicated in the maintenance of neuronal health.
Pathways
WDR37 interacts with critical protein networks involved in the PI3K/AKT signaling pathway. This pathway is significant for cell growth survival and metabolism. WDR37's associations within this pathway influence important molecular cascades and involve interactions with proteins like AKT and PI3K helping to coordinate cellular responses. WDR37 is also involved in the Wnt signaling pathway vital for gene expression regulation and developmental processes.
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Target data
Publications (1)
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The Journal of cell biology 221: PubMed34747980
2021
Applications
Unspecified application
Species
Unspecified reactive species
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