Rabbit Polyclonal WDR47 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 47 aa 200-300.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/20.00000 - 1/50.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
KIAA0893, KIAA0893, WDR47, WD repeat-containing protein 47, Neuronal enriched MAP-interacting protein, Nemitin
Rabbit Polyclonal WDR47 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 47 aa 200-300.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
WDR47 also known as WD repeat domain 47 is a protein with a molecular weight of approximately 45 kDa. This protein features several WD40 repeats which are structural motifs often linked to protein-protein interactions. WDR47 is mainly expressed in the brain and in some other tissues. It shows high expression during brain development suggesting its involvement in this process. The mechanical role of WDR47 involves acting as a scaffold facilitating various molecular interactions necessary for cellular mechanisms.
WDR47 is important for regulating processes such as cell migration and neuronal development. WDR47 is part of a multiprotein complex interacting with other key proteins that assist in coordinating cellular dynamics. These interactions help manage the assembly and breakdown of cytoskeletal elements which are vital to maintain cell shape and enable movement. In turn these processes influence neural growth and repair affecting the formation of neural circuits.
WDR47 integrates into signaling networks that manage cellular morphology and signaling in neurons. It plays significant roles in pathways like the Wnt signaling pathway and the neuronal polarization process. Within these pathways WDR47 interacts with proteins such as Dishevelled (Dvl) and APC contributing to cellular communication processes essential for proper neuron alignment and pathway signaling. The involvement in these pathways highlights WDR47's role in establishing and maintaining cellular architecture and signal transmission.
Disruptions in WDR47 can relate to neurological conditions such as intellectual disability and developmental brain disorders. Altered expression or mutations of WDR47 have implications for these conditions often influencing other proteins like Dvl and other cytoskeletal components involved in neural signaling and structural maintenance. Understanding the exact role of WDR47 in these diseases can potentially reveal targeted approaches for therapeutic strategies.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunocytochemistry analysis of human cell line U-2 OS labelling WDR47 with ab121935 at 2 μg/mL
ab121935, at 1/40 dilution, staining WDR47 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
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