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Rabbit Polyclonal WDR47 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 47 aa 200-300.

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Images

Immunocytochemistry - Anti-WDR47 antibody (AB121935), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR47 antibody (AB121935), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human WD repeat-containing protein 47 aa 200-300. The exact immunogen used to generate this antibody is proprietary information. Database link O94967

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PICC
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/20.00000 - 1/50.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Tested
Tested

Species

Human

Dilution info

-

Notes

-

Alternative names

Recommended products

Rabbit Polyclonal WDR47 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 47 aa 200-300.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human WD repeat-containing protein 47 aa 200-300. The exact immunogen used to generate this antibody is proprietary information. Database link O94967
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

WDR47 also known as WD repeat domain 47 is a protein with a molecular weight of approximately 45 kDa. This protein features several WD40 repeats which are structural motifs often linked to protein-protein interactions. WDR47 is mainly expressed in the brain and in some other tissues. It shows high expression during brain development suggesting its involvement in this process. The mechanical role of WDR47 involves acting as a scaffold facilitating various molecular interactions necessary for cellular mechanisms.

Biological function summary

WDR47 is important for regulating processes such as cell migration and neuronal development. WDR47 is part of a multiprotein complex interacting with other key proteins that assist in coordinating cellular dynamics. These interactions help manage the assembly and breakdown of cytoskeletal elements which are vital to maintain cell shape and enable movement. In turn these processes influence neural growth and repair affecting the formation of neural circuits.

Pathways

WDR47 integrates into signaling networks that manage cellular morphology and signaling in neurons. It plays significant roles in pathways like the Wnt signaling pathway and the neuronal polarization process. Within these pathways WDR47 interacts with proteins such as Dishevelled (Dvl) and APC contributing to cellular communication processes essential for proper neuron alignment and pathway signaling. The involvement in these pathways highlights WDR47's role in establishing and maintaining cellular architecture and signal transmission.

Associated diseases and disorders

Disruptions in WDR47 can relate to neurological conditions such as intellectual disability and developmental brain disorders. Altered expression or mutations of WDR47 have implications for these conditions often influencing other proteins like Dvl and other cytoskeletal components involved in neural signaling and structural maintenance. Understanding the exact role of WDR47 in these diseases can potentially reveal targeted approaches for therapeutic strategies.

Product promise

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2 product images

  • Immunocytochemistry - Anti-WDR47 antibody (ab121935), expandable thumbnail

    Immunocytochemistry - Anti-WDR47 antibody (ab121935)

    Immunocytochemistry analysis of human cell line U-2 OS labelling WDR47 with ab121935 at 2 μg/mL

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR47 antibody (ab121935), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR47 antibody (ab121935)

    ab121935, at 1/40 dilution, staining WDR47 in paraffin-embedded Human kidney tissue by Immunohistochemistry.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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