Anti-WDR62 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

WDR62 also known as WD repeat-containing protein 62 is a protein with a molecular mass of approximately 152 kDa. It localizes predominantly in the cytoplasm and the spindle poles of dividing cells. The protein contains several WD40 repeats which are motifs critical for protein-protein interactions. WDR62 is expressed in various tissues including the brain suggesting a significant function in neural development.

Biological function summary

WDR62 plays an essential role in neurogenesis by influencing cell proliferation and differentiation. It is a component of the spindle assembly complex ensuring proper chromosomal segregation during cell division. The protein is particularly active during mitosis where it participates in establishing spindle pole organization. Proper function of WDR62 is necessary for maintaining the integrity of the neuronal population in the developing brain.

Pathways

Spindle assembly and mitotic progression heavily involve WDR62. It interacts with Aurora A kinase an important player in the mitotic checkpoint pathway allowing accurate chromosome alignment and segregation. WDR62 also associates with c-Jun N-terminal kinase (JNK) signaling which impacts cell cycle regulation and apoptosis. These interactions suggest that WDR62 plays a role in ensuring normal cell division and viability.

Associated diseases and disorders

Mutations in WDR62 often lead to microcephaly a condition characterized by reduced brain size and intellectual disability. This link highlights the protein's critical function in brain development. Additionally aberrations in WDR62 might contribute to epileptic syndromes reflecting its involvement in neuronal health. In these disorders it interacts with proteins such as ASPM and CEP152 which are also implicated in microcephaly and cortical malformations.