Rabbit Polyclonal WDR72 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 72 aa 250-400.
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- Journal of periodontal research 58:1235-12472023Long non-coding RNA X-Inactive Specific Transcript (XIST) interacting with USF2 promotes osteogenic differentiation of periodontal ligament stem cells through regulation of WDR72 transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKe Xu,Ya-Dong Li,Liu-Yang Ren,Hai-Long Song,Qiao-Yun Yang,Dong-Liang XuPubMed 37712743
- Frontiers in cell and developmental biology 11:11616672023Identification and verification of a prognostic signature based on a miRNA-mRNA interaction pattern in colon adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQiwu Zhao,Haosheng Li,Wenchang Li,Zichao Guo,Wenqing Jia,Shuiyu Xu,Sixia Chen,Xiaonan Shen,Changgang WangPubMed 37745305
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human WD repeat-containing protein 72 aa 250-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q3MJ13
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Orangutan | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Orangutan | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.
Alternative names
WD repeat-containing protein 72, WDR72
Recommended products
Rabbit Polyclonal WDR72 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 72 aa 250-400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human WD repeat-containing protein 72 aa 250-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q3MJ13
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
WDR72 also known as WD repeat domain 72 is a protein that mechanically functions as a scaffolding unit. This protein enables the assembly of multi-protein complexes essential for maintaining cellular homeostasis. WDR72 has a molecular mass of approximately 110 kDa. It is expressed widely in tissues with significant levels found in the kidneys liver and the brain. This distribution suggests its importance in diverse bodily processes.
- Biological function summary
Four roles that the WDR72 protein is involved in include processes related to enamel formation cellular signaling and vesicle transport. WDR72 contributes as a part of a protein complex that regulates ameloblast differentiation which directly impacts enamel development. By facilitating vesicle movement within cells it helps maintain proper cellular activity particularly in the matrix formation of dental tissues.
- Pathways
Four key contributions in cellular signaling and enamel development rely on WDR72 functionality. It plays a role in the extracellular signal-regulated kinase (ERK) pathway important for transmitting signals from the cell membrane to the nucleus affecting cell division and survival. WDR72 is linked with proteins such as AMEL and ENAM which are significant within the pathway regulating tooth mineralization and calcification processes essential for strong enamel formation.
- Associated diseases and disorders
Four significant connections exist between WDR72 mutations and amelogenesis imperfecta a hereditary condition marked by defective enamel formation. This connection implicates WDR72 in dental health and integrity. Additionally malfunction or aberrations in WDR72 can relate to renal pathologies due to its expression in kidneys. Within the context of amelogenesis imperfecta WDR72 is connected with AMBN an ameloblast-associated protein highlighting their interaction during enamel formation and pathology when disrupted.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR72 antibody (ab188518)
Immunohistochemistry staining of paraffin embedded Human kidney tissue labeling WDR72 using ab188518 at a 1/1000 dilution.
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