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AB188518

Anti-WDR72 antibody

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(3 Publications)

Rabbit Polyclonal WDR72 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WD repeat-containing protein 72 aa 250-400.

View Alternative Names

WD repeat-containing protein 72, WDR72

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR72 antibody (AB188518)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR72 antibody (AB188518)

Immunohistochemistry staining of paraffin embedded Human kidney tissue labeling WDR72 using ab188518 at a 1/1000 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human WD repeat-containing protein 72 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q3MJ13

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WDR72 also known as WD repeat domain 72 is a protein that mechanically functions as a scaffolding unit. This protein enables the assembly of multi-protein complexes essential for maintaining cellular homeostasis. WDR72 has a molecular mass of approximately 110 kDa. It is expressed widely in tissues with significant levels found in the kidneys liver and the brain. This distribution suggests its importance in diverse bodily processes.
Biological function summary

Four roles that the WDR72 protein is involved in include processes related to enamel formation cellular signaling and vesicle transport. WDR72 contributes as a part of a protein complex that regulates ameloblast differentiation which directly impacts enamel development. By facilitating vesicle movement within cells it helps maintain proper cellular activity particularly in the matrix formation of dental tissues.

Pathways

Four key contributions in cellular signaling and enamel development rely on WDR72 functionality. It plays a role in the extracellular signal-regulated kinase (ERK) pathway important for transmitting signals from the cell membrane to the nucleus affecting cell division and survival. WDR72 is linked with proteins such as AMEL and ENAM which are significant within the pathway regulating tooth mineralization and calcification processes essential for strong enamel formation.

Four significant connections exist between WDR72 mutations and amelogenesis imperfecta a hereditary condition marked by defective enamel formation. This connection implicates WDR72 in dental health and integrity. Additionally malfunction or aberrations in WDR72 can relate to renal pathologies due to its expression in kidneys. Within the context of amelogenesis imperfecta WDR72 is connected with AMBN an ameloblast-associated protein highlighting their interaction during enamel formation and pathology when disrupted.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a major role in formation of tooth enamel (PubMed : 19853237, PubMed : 25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.
See full target information WD repeat-containing protein 72
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The Tohoku journal of experimental medicine : PubMed41062300

2025

Identification of KLHL35, WDR72, and WDR78 as Prognostic Biomarkers in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayou Ye,Tingting Zhang,Guangsheng Wang,Guofeng Bian,Aijun Chen,Xin Zhou

Journal of periodontal research 58:1235-1247 PubMed37712743

2023

Long non-coding RNA X-Inactive Specific Transcript (XIST) interacting with USF2 promotes osteogenic differentiation of periodontal ligament stem cells through regulation of WDR72 transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Xu,Ya-Dong Li,Liu-Yang Ren,Hai-Long Song,Qiao-Yun Yang,Dong-Liang Xu

Frontiers in cell and developmental biology 11:1161667 PubMed37745305

2023

Identification and verification of a prognostic signature based on a miRNA-mRNA interaction pattern in colon adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qiwu Zhao,Haosheng Li,Wenchang Li,Zichao Guo,Wenqing Jia,Shuiyu Xu,Sixia Chen,Xiaonan Shen,Changgang Wang
View all publications
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