JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB169597

Anti-WDR9/BRWD1 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Mouse Polyclonal WDR9/BRWD1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BRWD1.

View Alternative Names

C21orf107, WDR9, BRWD1, Bromodomain and WD repeat-containing protein 1, WD repeat-containing protein 9

1 Images
Western blot - Anti-WDR9/BRWD1 antibody (AB169597)
  • WB

Unknown

Western blot - Anti-WDR9/BRWD1 antibody (AB169597)

All lanes:

Western blot - Anti-WDR9/BRWD1 antibody (ab169597) at 1 µg/mL

Lane 1:

WDR9/BRWD1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 263 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human BRWD1.

Q9NSI6

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The WDR9/BRWD1 protein is also known by its alternate name BRWD1 and has a molecular mass of approximately 250 kDa. This protein shows expression in various tissues with higher levels observed in testis and certain brain regions. WDR9/BRWD1 is a member of the WD-repeat protein family and contains two bromodomains. Mechanically it plays a role in mediating protein-protein interactions aiding in chromatin organization and gene regulation.
Biological function summary

WDR9/BRWD1 functions in regulating transcriptional processes and is often part of nuclear chromatin complexes. It participates in gene expression important for spermatogenesis and neuronal differentiation. This protein interacts with other chromatin-modifying proteins contributing to the alteration of chromatin states and affecting cellular programs.

Pathways

Different regulatory and developmental processes involve WDR9/BRWD1. The protein plays roles within chromatin remodeling pathways. It engages with pathways such as histone modification and transcriptional regulation working alongside proteins like histones and other transcription factors which helps coordinate the accessibility of transcriptional machinery to DNA.

Abnormal WDR9/BRWD1 expression or mutations have connections to neurological and reproductive conditions. Studies link its dysregulation to intellectual disabilities and fertility issues. Its association with chromatin-modifying proteins implicates it in diseases where gene expression regulation plays a role such as certain cognitive disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
See full target information BRWD1
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Human genetics 140:761-773 PubMed33389130

2021

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Guo,Chao-Feng Tu,Dan-Hui Yang,Shui-Zi Ding,Cheng Lei,Rong-Chun Wang,Lv Liu,Xi Kang,Xiao-Qing Shen,Yi-Feng Yang,Zhi-Ping Tan,Yue-Qiu Tan,Hong Luo

International journal of clinical and experimental pathology 11:2488-2496 PubMed31938361

2018

Effects of melatonin on diabetic nephropathy rats via Wnt/β-catenin signaling pathway and TGF-β-Smad signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Weichao Wang,Jie Zhang,Xiaohang Wang,Hong Wang,Qiaohua Ren,Yukun Li
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB195164

Recombinant Human WDR9/BRWD1 protein

SDS-PAGE - Recombinant Human WDR9/BRWD1 protein (AB195164)

  • 0
  • 0
Primary Antibodies

AB169079

Anti-ZNF593 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF593 antibody (AB169079)

  • 0
  • 0
Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0
Proteins & Peptides

AB285976

Recombinant EN-TEV Protease protein

Bioactive

Size Exclusion Chromatography - Recombinant EN-TEV Protease protein (AB285976)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com