Anti-WDR91 antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The WDR91 protein also known as WD repeat domain 91 functions mechanistically by interacting with phosphatidylinositol 3-phosphate a lipid important for cellular processes. WDR91 has approximately a molecular weight of 90 kDa. It is expressed in various tissues with high levels found in the brain where it plays a significant role in cellular mechanisms. It contains WD40 repeats known for facilitating protein-protein interactions which are vital for its function in cellular processes.

Biological function summary

WDR91 facilitates endosomal signaling and trafficking processes. It assists in the proper sorting and recycling of receptors that regulate cellular responses. WDR91 forms part of a protein complex that includes key players like PIKFYVE which influences lipid synthesis on endosomal membranes. This involvement highlights its role in maintaining balanced cellular responses to environmental signals impacting overall cellular health.

Pathways

The activities of WDR91 integrate into the endosomal sorting and phosphoinositide signaling pathways. In the endosomal sorting pathway it collaborates with proteins like VPS34 and VPS15 to regulate endosome maturation. Through its function in phosphoinositide signaling it impacts aspects of cellular metabolism and organization affecting pathways linked to cellular growth and survival.

Associated diseases and disorders

WDR91 is related to a few neurological conditions. Mutations or dysregulation of WDR91 contributes to neurodegenerative disorders such as Alzheimer’s Disease. It associates with proteins like PIKFYVE in disease contexts where disruptions can lead to the accumulation of undefined cellular debris. A better understanding of WDR91 in these disease pathways may offer new insights into potential therapeutic approaches for such debilitating conditions.