JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB123375

Anti-WISP2 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal WISP2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CCN5 aa 200 to C-terminus.

View Alternative Names

CT58, CTGFL, WISP2, UNQ228/PRO261, CCN5, CCN family member 5, Connective tissue growth factor-like protein, Connective tissue growth factor-related protein 58, WNT1-inducible-signaling pathway protein 2, CTGF-L, WISP-2

1 Images
Western blot - Anti-WISP2 antibody (AB123375)
  • WB

Unknown

Western blot - Anti-WISP2 antibody (AB123375)

All lanes:

Western blot - Anti-WISP2 antibody (ab123375) at 1/500 dilution

Lane 1:

A549 cell extract

Lane 2:

A431 cell extract

Predicted band size: 27 kDa,41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CCN5 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O76076

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p>Incubate membrane with diluted antibody in 5% nonfat milk, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking over night.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

WISP2 also known as WNT1-inducible signaling pathway protein 2 or CCN5 is a protein that weighs approximately 29 kDa. This protein belongs to the CCN family which includes connective tissue growth factor and nephroblastoma overexpressed gene. WISP2 expression appears in various human tissues particularly in the liver lung and breast tissues. It is known to engage in cellular processes often impacting cell growth and differentiation due to its role in signaling pathways.
Biological function summary

Researchers observe WISP2’s significant role in cell proliferation migration and anti-apoptotic activities. It is known to not be part of a larger protein complex. This protein influences cell behavior and works in modulating functions related to the extracellular matrix. This modulation aids cellular restructuring and organization which are essential processes in tissue repair and development.

Pathways

Studies demonstrate that WISP2 plays a role in the Wnt signaling and PI3K/Akt pathways. The presence of WISP2 in these pathways allows it to control signals that regulate cell growth and survival. Within these pathways WISP2 interacts with several proteins including beta-catenin and AKT1 which help in transmitting signals from cell surface receptors to the DNA in the nucleus influencing gene expression and cellular responses.

WISP2 shows relevance in cancer and fibrosis. Researchers study its expression in breast cancer noting that it impacts tumor development and progression by interacting with other proteins like estrogen receptor-alpha (ERα). Moreover in the context of fibrosis WISP2 may influence fibrotic processes possibly involving connective tissue growth factor (CTGF) which contributes to tissue scarring and thickening through extracellular matrix production.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
See full target information CCN5
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Current eye research 44:34-45 PubMed30198788

2018

Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammad Harun-Or-Rashid,Finn Hallböök
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB318186

Anti-SFRP2 antibody [EPR26088-157] - BSA and Azide free

Recombinant|RabMAb

Western blot - Anti-SFRP2 antibody [EPR26088-157] - BSA and Azide free (AB318186)

  • 0
  • 0
Primary Antibodies

AB224077

Anti-C2orf40/ECRG4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C2orf40/ECRG4 antibody (AB224077)

  • 0
  • 0
Primary Antibodies

AB263898

Anti-THBS4 antibody [EPR22922-232]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-THBS4 antibody [EPR22922-232] (AB263898)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com