AB189015

Anti-Wnt10a antibody

Name: Anti-Wnt10a antibody (ab189015) | Abcam
Brand: Abcam Limited
SKU: AB189015

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(1 Publication)

Rabbit Polyclonal Wnt10a antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein Wnt-10a.

View Alternative Names

Protein Wnt-10a, WNT10A

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10a antibody (AB189015)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10a antibody (AB189015)

Immunohistochemical analysis of formalin fixed, paraffin embedded human pancreas, (islet) tissue labeling Wnt10a with ab189015 at 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Protein Wnt-10a. The exact immunogen used to generate this antibody is proprietary information.

Q9GZT5

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Wnt10a also known as Wingless-type MMTV integration site family member 10A is a protein that plays an important role in cellular signaling. This protein has a molecular mass of approximately 46 kDa. Wnt10a is expressed in various tissues including skin teeth and hair follicles where it is involved in mediating several cellular processes. The protein participates in signaling events by binding to specific receptors on the cell surface initiating a cascade of intracellular activities that influence development and cell differentiation.

Biological function summary

The Wnt10a protein is involved in the regulation of development and differentiation of ectodermal organs. It acts as a ligand in the Wnt signaling pathway which is a critical component of developmental processes. Wnt10a does not form complexes with others but binds to Frizzled receptors on the cell surface to propagate signals inside the cell. These signaling events guide proper formation and functioning of skin hair teeth and certain other structures influencing tissue maintenance and growth.

Pathways

Wnt10a plays a major role in the Wnt signaling pathways specifically the canonical Wnt/β-catenin pathway. This pathway is essential for gene transcription regulation and Wnt10a activates this through interaction with Frizzled and LRP co-receptors. Wnt10a's function is particularly related to the control of gene expression necessary for embryonic development and cell proliferation often working alongside other Wnt family proteins such as Wnt10b to regulate these pathways.

Wnt10a has associations with ectodermal dysplasia and tooth agenesis. Mutations in the Wnt10a gene can result in developmental disorders affecting skin hair and teeth due to its role in ectodermal organ formation. Additionally reduced Wnt10a function is linked with conditions such as osteoporosis where bone density is compromised. The protein’s interaction with other Wnt proteins in these disorders highlights the intricate balance of the Wnt signaling network in maintaining tissue and organ health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed : 17847007, PubMed : 28589954). Required for normal tooth development (PubMed : 17847007, PubMed : 28589954, PubMed : 29178643). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed : 28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed : 28589954). Required for normal hair follicle function (PubMed : 28589954).

See full target information Protein Wnt-10a

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

NPJ genomic medicine 9:18 PubMed38429302

2024

Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies.

Applications

Unspecified application

Species

Unspecified reactive species

Jil D Stegmann,Jeshurun C Kalanithy,Gabriel C Dworschak,Nina Ishorst,Enrico Mingardo,Filipa M Lopes,Yee Mang Ho,Phillip Grote,Tobias T Lindenberg,Öznur Yilmaz,Khadija Channab,Steve Seltzsam,Shirlee Shril,Friedhelm Hildebrandt,Felix Boschann,André Heinen,Angad Jolly,Katherine Myers,Kim McBride,Mir Reza Bekheirnia,Nasim Bekheirnia,Marcello Scala,Manuela Morleo,Vincenzo Nigro,Annalaura Torella,Michele Pinelli,Valeria Capra,Andrea Accogli,Silvia Maitz,Alice Spano,Rory J Olson,Eric W Klee,Brendan C Lanpher,Se Song Jang,Jong-Hee Chae,Philipp Steinbauer,Dietmar Rieder,Andreas R Janecke,Julia Vodopiutz,Ida Vogel,Jenny Blechingberg,Jennifer L Cohen,Kacie Riley,Victoria Klee,Laurence E Walsh,Matthias Begemann,Miriam Elbracht,Thomas Eggermann,Arzu Stoppe,Kyra Stuurman,Marjon van Slegtenhorst,Tahsin Stefan Barakat,Maureen S Mulhern,Tristan T Sands,Cheryl Cytrynbaum,Rosanna Weksberg,Federica Isidori,Tommaso Pippucci,Giulia Severi,Francesca Montanari,Michael C Kruer,Somayeh Bakhtiari,Hossein Darvish,Heiko Reutter,Gregor Hagelueken,Matthias Geyer,Adrian S Woolf,Jennifer E Posey,James R Lupski,Benjamin Odermatt,Alina C Hilger

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Wnt10a antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10a antibody (AB189015)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise