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AB217632

Anti-Wnt10b antibody

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(1 Publication)

Rabbit Polyclonal Wnt10b antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human WNT10B aa 200-300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

WNT12, WNT10B, Protein Wnt-10b, Protein Wnt-12

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10b antibody (AB217632)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10b antibody (AB217632)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded human kidney tissue labeling Wnt10b with ab217632 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10b antibody (AB217632)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt10b antibody (AB217632)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded mouse heart tissue labeling Wnt10b with ab217632 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human WNT10B aa 200-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O00744

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Wnt10b also known as wingless-related integration site 10b is a protein involved in signaling pathways critical for development and cellular processes. It has a molecular mass of approximately 46 kDa. This protein is mainly expressed in tissues like skin lung and adipose tissue. Wnt10b belongs to the broader Wnt family which is involved in mediating several signaling events during development.
Biological function summary

Wnt10b influences cell fate decisions and plays a role in adipogenesis and osteogenesis. It is not standalone but part of the Wnt signaling complex involving interactions with other proteins such as Frizzled receptors and co-receptors like LRP5/6. Through these interactions Wnt10b influences the beta-catenin pathway impacting gene transcription and cellular differentiation.

Pathways

Wnt10b plays roles in the Wnt/beta-catenin and Wnt/JNK pathways. These pathways control embryonic development and are important for tissue homeostasis. Wnt10b activates beta-catenin which partners with TCF/LEF transcription factors to modulate the expression of target genes. This protein shows functional similarity and connectivity with other Wnt family members such as Wnt3a which also engages in beta-catenin signaling.

Wnt10b has associations with obesity and osteoporosis. Elevated Wnt10b expression can inhibit adipogenesis linking it to potential obesity resistance. Conversely dysregulated Wnt signaling including Wnt10b may impair bone density and result in osteoporosis. The protein's interaction with LRP5 is significant in bone mass regulation highlighting Wnt10b's role in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
See full target information WNT10B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 12: PubMed39200236

2024

The Impact of DAXX, HJURP and CENPA Expression in Uveal Melanoma Carcinogenesis and Associations with Clinicopathological Parameters.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandros Pergaris,Georgia Levidou,Georgios Mandrakis,Maria-Ioanna Christodoulou,Michail V Karamouzis,Jerzy Klijanienko,Stamatios Theocharis
View all publications
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Product promise

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