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AB150602

Anti-Wnt5b antibody

3

(1 Review)

|

(1 Publication)

Rabbit Polyclonal WNT5B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein Wnt-5b.

View Alternative Names

Protein Wnt-5b, WNT5B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt5b antibody (AB150602)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt5b antibody (AB150602)

Immunohistochemical analysis of formalin-fixed paraffin embedded Human prostate (following heat-induced antigen retrieval) labelling Wnt5b using ab150602 at 2.5 μg/ml .

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Protein Wnt-5b. The exact immunogen used to generate this antibody is proprietary information.

Q9H1J7

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except WNT5A (71%).

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Complementary Products

Primary Antibodies

AB227229

Anti-Wnt5a antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt5a antibody (AB227229)

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Primary Antibodies

AB150596

Anti-Wnt4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt4 antibody (AB150596)

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Primary Antibodies

AB50030

Anti-Wnt6 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Wnt6 antibody (AB50030)

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Primary Antibodies

AB109222

Anti-Wnt2/IRP antibody [EPR3101(2)]

RabMAb|Recombinant

Western blot - Anti-Wnt2/IRP antibody [EPR3101(2)] (AB109222)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Wnt5b also known as wingless-type MMTV integration site family member 5B is a protein that is part of the Wnt family. It has a mass of approximately 42 kilodaltons. Wnt5b is expressed in various tissues notably in marmoset and human prostate tissue. It acts as a signaling molecule involving in cell communication processes such as cell fate determination proliferation and migration.
Biological function summary

Wnt5b is involved in the regulation of embryonic development and is part of a non-canonical Wnt signaling pathway. It does not form a direct signaling complex but interacts with other proteins to execute its function. Wnt5b has a role in the modulation of cell polarity and movement being important for maintaining the structural integrity of tissues and the developmental processes.

Pathways

Wnt5b plays a role in the planar cell polarity pathway and the Wnt/Ca2+ pathway. It connects to proteins like Dishevelled and Calcium/Calmodulin-dependent protein kinase II (CaMKII) acting to regulate intracellular calcium levels and influence cytoskeletal rearrangement. These pathways are critical for several aspects of cellular function including embryogenesis and tissue maintenance.

Wnt5b is associated with the development and progression of certain cancers including prostate cancer. Changes in Wnt5b signaling can disrupt cell-to-cell communication and lead to tumor growth. Additionally links exist between Wnt5b and other proteins such as beta-catenin in the context of cancer. Understanding these connections can offer insights into potential therapeutic strategies aimed at modulating Wnt5b activity to treat disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
See full target information Protein Wnt-5b
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 293:16528-16545 PubMed30166344

2018

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Tian,Steven G Widen,Jun Yang,Thomas G Wood,Andrzej Kudlicki,Yingxin Zhao,Allan R Brasier
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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