Goat Polyclonal WNT9B antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human Protein Wnt-9b aa 150-200.
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Mouse | Tested |
Rat | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 0.30000-1.00000 µg/mL | Notes 1 hour primary incubation is recommended for this product. |
Species Human | Dilution info 0.30000-1.00000 µg/mL | Notes 1 hour primary incubation is recommended for this product. |
Species | Dilution info | Notes |
---|---|---|
Species Rat | Dilution info - | Notes - |
Select an associated product type
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).
WNT14B, WNT15, UNQ6973/PRO21956, WNT15, WNT9B, WNT14B, UNQ6973/PRO21956, Protein Wnt-9b, Protein Wnt-14b, Protein Wnt-15
Goat Polyclonal WNT9B antibody. Suitable for WB and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human Protein Wnt-9b aa 150-200.
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Liquid
Polyclonal
Affinity purification Immunogen
ab106928 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Wnt9b also known as Wingless-related integration site 9b is a protein important for cell signaling. It is part of the Wnt protein family with a mass of approximately 40 kDa. Scientists detect Wnt9b expression in several tissues including the kidney liver and certain cell types in the developing limb. The Wnt proteins play an important role in developmental processes through signaling pathways.
Wnt9b impacts critical cellular events by mediating signaling processes. It interacts with other proteins forming complexes that influence gene expression and cell fate determination. Wnt9b significantly contributes to embryonic development particularly in organogenesis such as kidney and limb formation. Researchers have noted its role in maintaining the balance between proliferation and differentiation in those tissues.
Current research has placed Wnt9b within the canonical Wnt/β-catenin signaling pathway and the non-canonical Wnt signaling pathway. These pathways involve important proteins like β-catenin in the canonical pathway which affects transcriptional regulation. Wnt9b also interacts with Frizzled receptors modulating downstream signaling effects. These pathways are essential in regulating cellular functions such as stem cell pluripotency and cellular differentiation.
Scientists have linked Wnt9b to developmental disorders and cancer. In kidney development mutations or altered expression can lead to renal dysplasia or agenesis disorders connected with other pathways and factors such as BMP4. In cancer biology aberrant Wnt9b signaling correlates with tumorigenesis particularly in hepatocellular carcinoma where it may interact with proteins like AXIN2 leading to altered cell cycle progression and proliferation. Understanding Wnt9b's involvement in these conditions offers potential for therapeutic targets.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-Wnt9b antibody (ab106928) at 1 µg/mL
Lane 1: mouse kidney tissue lysate at 35 µg
Lane 2: mouse brain tissue lysate at 35 µg
Predicted band size: 39 kDa
Observed band size: 38 kDa
Primary incubation was 1 hour.
All lanes: Western blot - Anti-Wnt9b antibody (ab106928) at 0.3 µg/mL
All lanes: Human Brain Cerebellum lysate in RIPA buffer at 35 µg
Developed using the ECL technique.
Predicted band size: 39 kDa
Observed band size: 38 kDa
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