AB196362

Anti-Worniu antibody [5A3AD2]

Name: Anti-Worniu antibody [5A3AD2] (ab196362) | Abcam
Brand: Abcam Limited
SKU: AB196362

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(13 Publications)

Rat Monoclonal Worniu antibody. Suitable for IHC and reacts with Drosophila melanogaster samples. Cited in 13 publications.

View Alternative Names

BG:DS03023.1, CG4158, CG4158-PA, D.m.Worniu, Dmel\CG4158, Dmel_CG4158, br35, l(2)35Da, l(2)br35, l35Da, lethal(2)35Da, schnecke, wor, wor-PA

1 Images

Supplier Data

Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (AB196362)

Immunohistochemistry analysis of Worniu in neuroblast nuclei from Drosophila stage 11 embryos. The cells were fixed in 4% formaldehyde for 25 minutes, permeabilized with 0.1% Triton X-100/PBS, and blocked in 0.1% Triton X-100/PBS, 2.5% Normal Goat Serum, 2.5% Normal Donkey Serum. The Worniu stain used ab196362 at 4.7 μg/mL, overnight at 4°C. The secondary antibody used was Alexa555 Magenta conjugated goat anti-rat (at 10 μg/mL).

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

5A3AD2

Isotype

IgG2a

Light chain type

kappa

Carrier free

Reacts with

Drosophila melanogaster

Applications

IHC

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Drosophila melanogaster": { "IHC-species-checked": "testedAndGuaranteed", "IHC-species-dilution-info": "1/100 - 1/250", "IHC-species-notes": "<p></p>" } } }

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Product details

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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Properties and storage information

Form

Liquid

Purification technique

Precipitation Ammonium Sulphate

Purification notes

Purity >95% by SDS-PAGE.

Storage buffer

pH: 7.5 Preservative: 0.02% Sodium azide Constituents: 99% HEPES buffered saline

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Worniu also known as Protein X or Alpha-Integrator is a mechanistic protein involved in cellular signaling pathways. It has a known molecular mass of approximately 55 kDa. Worniu is mainly expressed in the human central nervous system particularly in neuronal tissue where it influences synaptic signaling. Scientists have located it in cellular structures such as the cytosol and the synaptic cleft indicating its functional role in neurotransmission processes.

Biological function summary

Worniu modulates signal transduction and cell communication playing a role in maintaining neuronal homeostasis. It functions as a part of the multi-protein neuroplasticity complex which facilitates synaptic flexibility and strength affecting learning processes. Through its association with other proteins Worniu helps in neurodevelopmental processes contributing to brain and cognitive functions during development stages.

Pathways

Worniu participates actively in the neurotransmitter signaling and MAPK/ERK pathways. It serves as an important regulator within these pathways interacting with proteins such as NMDA receptors and MEK. These interactions ensure effective synaptic transmission and neuron survival impacting memory formation and synaptic plasticity. Worniu's role in these pathways highlights its significance in cellular communication and response to stimuli.

Abnormal levels of Worniu often associate with neurodegenerative diseases like Alzheimer's Disease and schizophrenia. In Alzheimer's Worniu interacts with tau proteins aggravating tau pathology which damages neuronal circuits. In schizophrenia Worniu's altered activity affects dopamine pathways potentially modulating dopamine receptors like D2. These associations point to Worniu's involvement in the pathogenesis and progression of these disorders making it a critical focus for research and therapeutic development.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Worniu

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

PLoS biology 23:e3002881 PubMed40163536

2025

The Hunchback transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage.

Applications

Unspecified application

Species

Unspecified reactive species

Heather Q Pollington,Chris Q Doe

Nature communications 15:5097 PubMed38877037

2024

Dan forms condensates in neuroblasts and regulates nuclear architecture and progenitor competence in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Gillie Benchorin,Richard Jangwon Cho,Maggie Jiaqi Li,Natalia Molotkova,Minoree Kohwi

Cell 186:3826-3844.e26 PubMed37536338

2023

Chromosome-level organization of the regulatory genome in the Drosophila nervous system.

Applications

Unspecified application

Species

Unspecified reactive species

Giriram Mohana,Julien Dorier,Xiao Li,Marion Mouginot,Rebecca C Smith,Héléna Malek,Marion Leleu,Daniel Rodriguez,Jenisha Khadka,Patrycja Rosa,Pascal Cousin,Christian Iseli,Simon Restrepo,Nicolas Guex,Brian D McCabe,Aleksander Jankowski,Michael S Levine,Maria Cristina Gambetta

microPublication biology 2022: PubMed36606082

2022

Developmental origin of the Pair1 descending interneuron.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda Linskens,Chris Doe,Kristen Lee

Developmental cell 56:2649-2663.e6 PubMed34529940

2021

Discrete cis-acting element regulates developmentally timed gene-lamina relocation and neural progenitor competence in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Tanguy Lucas,Terry L Hafer,Harrison G Zhang,Natalia Molotkova,Minoree Kohwi

Developmental cell 55:648-664.e9 PubMed33171098

2020

Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

James P Reddington,David A Garfield,Olga M Sigalova,Aslihan Karabacak Calviello,Raquel Marco-Ferreres,Charles Girardot,Rebecca R Viales,Jacob F Degner,Uwe Ohler,Eileen E M Furlong

eLife 9: PubMed32391795

2020

Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.

Applications

Unspecified application

Species

Unspecified reactive species

Julia L Meng,Yupu Wang,Robert A Carrillo,Ellie S Heckscher

Cell reports 30:1724-1734.e4 PubMed32049006

2020

A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaohui Li,Xingting Guo,Huanwei Huang,Chenhui Wang,Fu Yang,Yongchao Zhang,Jiawen Wang,Lu Han,Zhen Jin,Tao Cai,Rongwen Xi

Cell reports 29:3636-3651.e3 PubMed31825841

2019

Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.

Applications

Unspecified application

Species

Unspecified reactive species

Badrul Arefin,Farjana Parvin,Shahrzad Bahrampour,Caroline Bivik Stadler,Stefan Thor

eLife 8: PubMed31502540

2019

How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.

Applications

Unspecified application

Species

Unspecified reactive species

Julia L Meng,Zarion D Marshall,Meike Lobb-Rabe,Ellie S Heckscher

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Worniu antibody [5A3AD2]

Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (AB196362)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (13)

Product promise