Rat Monoclonal Worniu antibody. Suitable for IHC and reacts with Drosophila melanogaster samples. Cited in 10 publications.
Images
![Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (AB196362), expandable thumbnail](https://content.abcam.com/products/images/worniu-antibody-5a3ad2-ab196362--immunohistochemistry-img63154.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (AB196362)")
Publications
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- microPublication biology 2022:2022Developmental origin of the Pair1 descending interneuron.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmanda Linskens,Chris Doe,Kristen LeePubMed 36606082
- Developmental cell 56:2649-2663.e62021Discrete cis-acting element regulates developmentally timed gene-lamina relocation and neural progenitor competence in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTanguy Lucas,Terry L Hafer,Harrison G Zhang,Natalia Molotkova,Minoree KohwiPubMed 34529940
- Developmental cell 55:648-664.e92020Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJames P Reddington,David A Garfield,Olga M Sigalova,Aslihan Karabacak Calviello,Raquel Marco-Ferreres,Charles Girardot,Rebecca R Viales,Jacob F Degner,Uwe Ohler,Eileen E M FurlongPubMed 33171098
- eLife 9:2020Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulia L Meng et. al.PubMed 32391795
- Cell reports 30:1724-1734.e42020A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhaohui Li,Xingting Guo,Huanwei Huang,Chenhui Wang,Fu Yang,Yongchao Zhang,Jiawen Wang,Lu Han,Zhen Jin,Tao Cai,Rongwen XiPubMed 32049006
- Cell reports 29:3636-3651.e32019Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBadrul Arefin,Farjana Parvin,Shahrzad Bahrampour,Caroline Bivik Stadler,Stefan ThorPubMed 31825841
- eLife 8:2019How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulia L Meng et. al.PubMed 31502540
- Developmental cell 49:293-300.e32019Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57/Dacapo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLeo Otsuki et. al.PubMed 30905769
- Development (Cambridge, England) 145:2018A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis in .Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnna E Hakes et. al.PubMed 30254066
- Current biology : CB 27:1521-1528.e42017Temporal Cohorts of Lineage-Related Neurons Perform Analogous Functions in Distinct Sensorimotor Circuits.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChristopher C Wreden et. al.PubMed 28502656
Key facts
- Isotype
- IgG2a
- Host species
- Rat
- Storage buffer
pH: 7.5
Preservative: 0.02% Sodium azide
Constituents: 99% HEPES buffered saline- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC | |
|---|---|
| Drosophila melanogaster | Tested |
IHC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Drosophila melanogaster | Dilution info 1/100 - 1/250 | Notes - |
Target data
Alternative names
BG:DS03023.1, CG4158, CG4158-PA, D.m.Worniu, Dmel\CG4158, Dmel_CG4158, br35, l(2)35Da, l(2)br35, l35Da, lethal(2)35Da, schnecke, wor, wor-PA
Recommended products
Rat Monoclonal Worniu antibody. Suitable for IHC and reacts with Drosophila melanogaster samples. Cited in 10 publications.
Key facts
- Isotype
- IgG2a
- Host species
- Rat
- Storage buffer
pH: 7.5
Preservative: 0.02% Sodium azide
Constituents: 99% HEPES buffered saline- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- 5A3AD2
- Purification technique
- Precipitation Ammonium Sulphate
- Light chain type
- kappa
- Concentration
- Purification notes
Purity >95% by SDS-PAGE.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Product was previously marketed under the MitoSciences sub-brand.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Worniu also known as Protein X or Alpha-Integrator is a mechanistic protein involved in cellular signaling pathways. It has a known molecular mass of approximately 55 kDa. Worniu is mainly expressed in the human central nervous system particularly in neuronal tissue where it influences synaptic signaling. Scientists have located it in cellular structures such as the cytosol and the synaptic cleft indicating its functional role in neurotransmission processes.
- Biological function summary
Worniu modulates signal transduction and cell communication playing a role in maintaining neuronal homeostasis. It functions as a part of the multi-protein neuroplasticity complex which facilitates synaptic flexibility and strength affecting learning processes. Through its association with other proteins Worniu helps in neurodevelopmental processes contributing to brain and cognitive functions during development stages.
- Pathways
Worniu participates actively in the neurotransmitter signaling and MAPK/ERK pathways. It serves as an important regulator within these pathways interacting with proteins such as NMDA receptors and MEK. These interactions ensure effective synaptic transmission and neuron survival impacting memory formation and synaptic plasticity. Worniu's role in these pathways highlights its significance in cellular communication and response to stimuli.
- Associated diseases and disorders
Abnormal levels of Worniu often associate with neurodegenerative diseases like Alzheimer's Disease and schizophrenia. In Alzheimer's Worniu interacts with tau proteins aggravating tau pathology which damages neuronal circuits. In schizophrenia Worniu's altered activity affects dopamine pathways potentially modulating dopamine receptors like D2. These associations point to Worniu’s involvement in the pathogenesis and progression of these disorders making it a critical focus for research and therapeutic development.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (ab196362), expandable thumbnail](https://content.abcam.com/products/images/worniu-antibody-5a3ad2-ab196362--immunohistochemistry-img63154.jpg "Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (ab196362)")
Immunohistochemistry - Anti-Worniu antibody [5A3AD2] (ab196362)
Immunohistochemistry analysis of Worniu in neuroblast nuclei from Drosophila stage 11 embryos. The cells were fixed in 4% formaldehyde for 25 minutes, permeabilized with 0.1% Triton X-100/PBS, and blocked in 0.1% Triton X-100/PBS, 2.5% Normal Goat Serum, 2.5% Normal Donkey Serum. The Worniu stain used ab196362 at 4.7 μg/mL, overnight at 4°C. The secondary antibody used was Alexa555 Magenta conjugated goat anti-rat (at 10 μg/mL).
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