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AB134805

Anti-XAGE1 antibody

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(2 Publications)

Goat Polyclonal XAGE1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human XAGE1A aa 50 to C-terminus.

View Alternative Names

GAGED2, XAGE1, XAGE1B, XAGE1C, XAGE1D, XAGE1E, XAGE1A, X antigen family member 1, XAGE-1, Cancer/testis antigen 12.1, G antigen family D member 2, CT12.1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XAGE1 antibody (AB134805)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XAGE1 antibody (AB134805)

Immunohistochemistry analysis of Formalin fixed and Paraffin Embedded (IHC-P) Human Testis tissue labelling XAGE1 with ab134805 at 3.75 µg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XAGE1 antibody (AB134805)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XAGE1 antibody (AB134805)

Immunohistochemistry analysis of Formalin fixed and Paraffin Embedded (IHC-P) Human Placenta tissue labelling XAGE1 with ab134805 at 3.75 µg/ml.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human XAGE1A aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9HD64

Specificity

This antibody is expected to recognise isoform d (NP_597673.1) only. Reported variants represent identical protein (NP_597673.1; NP_001091067.1; NP_001091074.1; NP_001091062.1; NP_001091065.1).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

XAGE1 also known as GAGED2b is a cancer/testis antigen with a molecular mass of approximately 14 kDa. This protein is expressed primarily in testicular tissue and several types of cancer but shows limited expression in normal somatic tissues. XAGE1 locates in the cytoplasm of cells and may shuttle between cellular compartments depending on context. Researchers value XAGE1 as a biomarker due to its restricted expression pattern.
Biological function summary

XAGE1 impacts cell proliferation and immune response modulation. The protein does not form part of known complexes operating more as an individual player in cellular mechanisms. Its presence directly ties to cellular processes that control growth and survival suggesting roles in balancing cell cycle regulation and apoptosis. Elevated levels of XAGE1 can alter the cellular environment affecting various biological processes.

Pathways

The activity of XAGE1 integrates with growth signaling and immunogenic pathways. One critical pathway involves its role in modulating immune recognition of cancer cells. XAGE1 influences interactions within the tumor necrosis factor (TNF) superfamily potentially affecting the NF-kB signaling pathway. This relation suggests heightened expression of XAGE1 might further interactions with proteins like TNF-alpha and could modulate inflammatory responses or contribute to tumor immunity evasion.

XAGE1 has significant links to cancer particularly in lung and prostate malignancies. Enhanced expression in these cancers implies a potential influence on cancer progression and immune escape. Its connection to prostate cancer involves interactions with the androgen receptor pathway which is vital in disease development. Its expression patterns and regulatory roles can provide insights into cancer diagnostics and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information XAGE1A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 13:1106434 PubMed37081973

2023

Tumor immune microenvironment of cutaneous angiosarcoma with cancer testis antigens and the formation of tertiary lymphoid structures.

Applications

Unspecified application

Species

Unspecified reactive species

Tetsuya Magara,Motoki Nakamura,Yuka Nojiri,Maki Yoshimitsu,Shinji Kano,Hiroshi Kato,Akimichi Morita

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 37:14605-14614 PubMed27619677

2016

miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qijue Lu,Li Xu,Chunguang Li,Yang Yuan,Shengdong Huang,Hezhong Chen
View all publications
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Product promise

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