Anti-XYLB antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The XYLB protein also known as xylulose kinase plays a significant mechanical role in carbohydrate metabolism. It is a 57 kDa enzyme responsible for catalyzing the phosphorylation of xylulose a five-carbon sugar into xylulose-5-phosphate. This activity is important in the pentose phosphate pathway and is highly expressed in the liver kidney and intestine tissues where glucose and fructose metabolism primarily occur.

Biological function summary

Xylulose kinase contributes to the interconversion of carbohydrate molecules facilitating the utilization of xylose a sugar derived from plant biomass. While it does not directly function as part of a larger macromolecular complex XYLB supports the transformation of xylulose as part of the broader carbohydrate metabolic processes. It helps maintain a balance in energy metabolism and influences the flux of metabolites through various pathways in cells.

Pathways

Xylulose kinase is an important enzyme in the pentose phosphate pathway a pathway critical for nucleotide biosynthesis and antioxidant defense. This pathway interacts with glycolysis and is closely related to enzymes like transketolase and aldolase which further process sugar phosphates into energy-rich intermediates. XYLB's activity helps replenish metabolites into the glycolytic pathway connecting it to glucose metabolism and cellular respiration processes.

Associated diseases and disorders

Alterations in XYLB activity have implications in metabolic disorders such as diabetes and obesity. Disrupted xylose metabolism can contribute to imbalances in sugar processing and energy utilization potentially exacerbating symptoms of these conditions. Research indicates a potential interaction between XYLB and glucose-6-phosphate dehydrogenase an enzyme whose dysfunction is relevant in metabolic syndrome highlighting bxyulose kinase's role in systemic carbohydrate management.