Anti-Yellow Fever Virus antibody [3576]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The Yellow Fever Virus disrupts multiple cellular processes by hijacking the host cell’s machinery to propagate. Its RNA genome encodes a single polyprotein which further cleaves into individual proteins some of which form complexes to assist in viral replication and assembly. The virus employs these proteins to evade the host immune response ensuring its survival and proliferation within the host. As a result the infection culminates in severe damage to hepatic tissues and blood circulatory disturbances.

Pathways

Other flaviviruses like the Yellow Fever Virus exploit host cell pathways such as the ubiquitin-proteasome system and the ER-associated degradation (ERAD) pathway. These pathways enable efficient viral protein processing and replication. YFV proteins closely interact with host proteins involved in these cellular pathways such as heat shock proteins and chaperones which assist in viral replication and assembly through their functions in protein folding and stabilization.