Rabbit Polyclonal YIPF6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human YIPF6 aa 1-100.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Cow | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Cow | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
Species | Dilution info | Notes |
---|---|---|
Species Cow | Dilution info - | Notes - |
May be required for stable YIPF1 and YIPF2 protein expression.
Protein YIPF6, YIP1 family member 6, YIPF6
Rabbit Polyclonal YIPF6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human YIPF6 aa 1-100.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
YIPF6 also known as YIP1 family member 6 is a protein involved in vesicular transport and membrane trafficking. It has a molecular mass of approximately 35 kDa. The protein localizes primarily at the Golgi apparatus and is expressed in various tissues particularly in those with high secretory functions such as the liver and pancreas. YIPF6 plays a significant role in maintaining Golgi structure and function by interacting with other Golgi-associated proteins.
YIPF6 participates in the formation and maintenance of the Golgi complex. It functions as part of a larger protein complex collaborating with Rab Arf and other YIP family proteins to regulate vesicle budding and fusion. This activity is essential for proper protein and lipid trafficking within cells ensuring that the cellular export and import processes proceed efficiently. The protein's interactions with various co-factors highlight its role in sustaining intracellular logistics.
YIPF6 is an essential component of the vesicular transport system and intracellular trafficking pathways. It closely associates with the COPI (coat protein complex I) pathway which mediates retrograde transport from the Golgi to the endoplasmic reticulum. YIPF6 also engages in related functions with proteins such as ARF1 a small GTPase critical for vesicle formation. These pathways highlight the protein's role in facilitating cellular transport mechanisms that are important for maintaining homeostasis within the cell.
YIPF6's dysfunction can link to conditions involving protein misfolding and trafficking defects such as certain neurodegenerative diseases. Mutations or alterations in YIPF6 may also relate to metabolic disorders where liver and pancreatic functions are compromised. Its connection with proteins like Rab GTPases and ARF1 emphasizes its involvement in the underlying pathophysiology of these diseases as these associated proteins play roles in the same trafficking pathways that could lead to cellular stress and impairment when disrupted.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for YIPF6 (green) using ab224224 at 4 μg/ml in ICC/IF.
Paraffin-embedded human epididymis tissue stained for YIPF6 using ab224224 at 1/50 dilution in immunohistochemical analysis.
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