Rabbit Polyclonal YKT6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Synaptobrevin homolog YKT6 aa 1 to C-terminus.
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Publications
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- The Journal of neuroscience : the official journal of the Society for Neuroscience 42:5641-56542022Unbalanced Regulation of Sec22b and Ykt6 Blocks Autophagosome Axonal Retrograde Flux in Neuronal Ischemia-Reperfusion Injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaiying Li,Xiang Li,Zhongmou Xu,Jinxin Lu,Chang Cao,Wanchun You,Zhengquan Yu,Haitao Shen,Gang ChenPubMed 35654605
- International journal of molecular sciences 23:2022Comparison of the Cisterna Maturation-Progression Model with the Kiss-and-Run Model of Intra-Golgi Transport: Role of Cisternal Pores and Cargo Domains.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGalina V Beznoussenko,Hee-Seok Kweon,Irina S Sesorova,Alexander A MironovPubMed 35408951
- Oncoimmunology 10:19388902021, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZongcheng Yang,Guangxing Yan,Lixin Zheng,Wenchao Gu,Fen Liu,Wei Chen,Xiujie Cui,Yue Wang,Yaling Yang,Xiyan Chen,Yue Fu,Xin XuPubMed 34221701
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Synaptobrevin homolog YKT6 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O15498
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
| Cow | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
Alternative names
Synaptobrevin homolog YKT6, YKT6
Recommended products
Rabbit Polyclonal YKT6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Synaptobrevin homolog YKT6 aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Synaptobrevin homolog YKT6 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O15498
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purity >95%.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
YKT6 also known as Synaptobrevin-like 2 is a SNARE protein involved in vesicular transport. YKT6 has a molecular mass of about 23 kDa and is present across various tissues notably in the brain and pancreas. This protein does not have a transmembrane domain which allows cycling between membrane-bound and cytosolic forms contributing to its role in membrane fusion processes.
- Biological function summary
YKT6 aids in the regulation of membrane fusion events important for the secretory pathway. It operates as part of the SNARE complex which includes other proteins like VAMPs syntaxin and SNAP-25. These components form a tight complex that brings vesicle and target membranes into close proximity driving the fusion necessary for intracellular transport and secretion.
- Pathways
YKT6 connects to exocytosis and endocytosis pathways which are important for neurotransmitter release and cellular uptake processes. It interacts with proteins such as SNAP-25 and syntaxins within these pathways. As a SNARE protein YKT6's role in vesicle trafficking is vital for maintaining cellular homeostasis and regulating signal transmission across synapses.
- Associated diseases and disorders
Abnormalities in YKT6 expression or function impact neurodegenerative diseases like Alzheimer's disease. Altered interactions between YKT6 and other proteins such as syntaxin can disrupt normal synaptic function and contribute to pathogenesis. Additionally irregular YKT6 activity may play a role in certain cancers where vesicular transport and secretion are typically disrupted.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-YKT6 antibody (ab236583)
All lanes: Western blot - Anti-YKT6 antibody (ab236583) at 1/500 dilution
All lanes: A549 (Human lung carcinoma cell line) whole cell lysate
SecondaryAll lanes: Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 22 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YKT6 antibody (ab236583)
Paraffin-embedded human adrenal gland tissue stained for YKT6 with ab236583 at 1/100 dilution in immunohistochemical analysis.
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