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AB169461

Anti-Z-protein antibody

5

(2 Reviews)

|

(1 Publication)

Mouse Polyclonal Z-protein antibody - Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

GAAP, LFG4, CGI-119, TMBIM4, Protein lifeguard 4, Golgi anti-apoptotic protein, Protein S1R, Transmembrane BAX inhibitor motif-containing protein 4, Z-protein

1 Images
Western blot - Anti-Z-protein antibody (AB169461)
  • WB

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Western blot - Anti-Z-protein antibody (AB169461)

All lanes:

Western blot - Anti-Z-protein antibody (ab169461) at 1 µg/mL

Lane 1:

Z-protein transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 22 kDa,27 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TMBIM4.

Q9HC24

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 99% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Z-protein also known as Protein Z or ZP plays an important role in various biological processes. It is a small protein with a mass of approximately 62 kilodaltons. Researchers have found Z-protein to be expressed prominently in the liver and to some extent in the pancreas. Its expression levels suggest an involvement in important metabolic and signaling functions specific to these organs.
Biological function summary

Z-protein contributes to the regulation of coagulation. It is part of the coagulation cascade forming complexes with other key proteins to control blood clot formation. This protein interacts with the Z-dependent protease inhibitor (ZPI) which is essential for the inhibition of factor X and factor XI in the coagulation process. Through these interactions Z-protein maintains the balance between coagulation and anticoagulation preventing excessive clotting and bleeding.

Pathways

Z-protein activity significantly influences the coagulation and fibrinolysis pathways. Within the coagulation pathway it plays a cooperative role with proteins such as thrombin and antithrombin which further modulates the activation of clotting factors. In the fibrinolysis pathway it helps regulate plasmin activity ensuring proper clot resolution. These interactions highlight the protein's centrality to maintaining hemostatic balance.

Malfunction or deficiencies in Z-protein have been linked to an increased risk of thrombosis and cardiovascular disease. Its inadequate function may elevate the likelihood of abnormal clot formation particularly because of its relationship with the coagulation factors and Z-dependent protease inhibitor. Additionally research has shown connections between Z-protein deficiencies and liver diseases suggesting its involvement with the pathways impacting liver function and health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
See full target information TMBIM4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular and clinical oncology 7:991-999 PubMed29285362

2017

dTCApFs, a derivative of a novel human hormone peptide, induces apoptosis in cancer cells through a mechanism involving loss of Golgi function.

Applications

Unspecified application

Species

Unspecified reactive species

Joel Ohana,Uziel Sandler,Gideon Kass,Salomon M Stemmer,Yoram Devary
View all publications
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Product promise

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