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AB129875

Anti-ZAR1 antibody

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(1 Publication)

Rabbit Polyclonal ZAR1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Zygote arrest protein 1, ZAR1

1 Images
Western blot - Anti-ZAR1 antibody (AB129875)
  • WB

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Western blot - Anti-ZAR1 antibody (AB129875)

All lanes:

Western blot - Anti-ZAR1 antibody (ab129875) at 1/500 dilution

Lane 1:

293 cell lysate

Lane 2:

293 cell lysate with blocking peptide

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab129875 is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZAR1 also known as Zygote Arrest 1 is a protein involved in early embryonic development. It has a mass of approximately 42 kDa and is selectively expressed in oocytes and early embryos. ZAR1 plays an important role in regulating processes during oocyte maturation and embryogenesis. Its expression is mainly restricted to the female reproductive system particularly in the ovaries during developmental stages essential for fertilization and zygote formation.
Biological function summary

The activity of ZAR1 centers around its ability to control the cell cycle and maintain genomic stability. It acts as part of a regulatory complex that interacts with other proteins to ensure successful zygote development. ZAR1's role involves safeguarding the early stages of fertilization by stabilizing maternal mRNA and assisting in the transition from maternal to zygotic control. This protein is fundamental in the early phases of embryo development guiding processes that are instrumental for life continuation.

Pathways

ZAR1 is important in mechanisms such as the maternal-zygotic transition and cell cycle regulation pathways. ZAR1 collaborates with other proteins like YBX2 and DDX6 to facilitate these pathways ensuring a smooth transition of control from maternal to embryonic genome. Additionally it is involved in pathways that coordinate checkpoints during cell division illustrating its vital roles within highly regulated molecular frameworks essential for embryogenesis.

ZAR1 has associations with infertility and other reproductive issues. Abnormalities in ZAR1 function may disrupt normal embryo development leading to infertility or defective embryonic cell cycles. The protein interacts with other development-related proteins providing potential therapeutic targets for infertility treatments. Additionally ZAR1's dysfunction could contribute to fragmentary embryonic development increasing the risk for early pregnancy loss connecting it to disorders requiring further reproductive health research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation.
See full target information ZAR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecules (Basel, Switzerland) 25: PubMed33081083

2020

A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Romain Duroux,Anne Mandeau,Gaelle Guiraudie-Capraz,Yannick Quesnel,Estelle Loing
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Product promise

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