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AB185106

Anti-ZASC1 antibody

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(3 Publications)

Rabbit Polyclonal ZASC1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF639 aa 100-200.

View Alternative Names

ZASC1, ZNF639, Zinc finger protein 639, Zinc finger protein ANC_2H01, Zinc finger protein ZASC1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

Immunofluorescence analysis of MCF7 cells labeling ZASC1 using ab185106 at 4 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

Immunohistochemical analysis of paraffin-embedded Human rectum tissue, labeling ZASC1 using ab185106 at a 1/500 dilution.

Western blot - Anti-ZASC1 antibody (AB185106)
  • WB

Supplier Data

Western blot - Anti-ZASC1 antibody (AB185106)

All lanes:

Western blot - Anti-ZASC1 antibody (ab185106) at 1/500 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U251 MG sp lysate

Lane 3:

Human plasma (IgG/HSA depleted)

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 56 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZNF639 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9UID6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol</p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZASC1 also known as Zinc finger protein 618 with SCAN box is a transcription factor characterized by the presence of a SCAN domain and multiple zinc finger motifs. It has an approximate molecular mass of 93 kDa. This protein is largely expressed in the testis with lower levels present in additional tissues such as the heart and brain. The presence of zinc finger domains indicates its potential role in DNA binding and gene regulation.
Biological function summary

ZASC1 is involved in modulating the transcriptional activities of genes by binding to specific DNA sequences. In its function as a transcription factor ZASC1 interacts with other proteins to form a regulatory complex that influences gene expression patterns. This protein plays a role in cellular processes such as differentiation and proliferation by impacting the transcription of genes necessary for these processes.

Pathways

ZASC1 participates in several essential cellular pathways including those linked to gene expression regulation in the cell cycle. Within these pathways it works in conjunction with other transcription factors and signaling proteins such as the CREB-binding protein to fine-tune the transcriptional response. This interaction serves to coordinate the cellular activities important for maintaining normal function and development.

ZASC1 has implications in conditions like cancer and infertility. Altered expression or mutations in its coding sequence are associated with the dysregulation of cell growth implicating it in oncogenic processes. It also associates with other proteins like c-Myc in various cancer types highlighting its significance in cancer biology. Additionally inappropriate expression of ZASC1 may disrupt spermatogenesis leading to infertility highlighting its importance in reproductive health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds DNA and may function as a transcriptional repressor.
See full target information ZNF639
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of breast cancer 28:86-98 PubMed40133986

2025

Zinc Finger Protein 639 Expression Is a Novel Prognostic Determinant in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Lee,Shih-Ping Cheng,Ming-Jen Chen,Wen-Chien Huang,Yi-Min Liu,Shao-Chiang Chang,Yuan-Ching Chang

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:1648-1665 PubMed35017224

2022

KCTD8 and KCTD12 Facilitate Axonal Expression of GABA Receptors in Habenula Cholinergic Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yuqi Ren,Yang Liu,Sanduo Zheng,Minmin Luo

PLoS pathogens 17:e1009364 PubMed33635925

2021

ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.

Applications

Unspecified application

Species

Unspecified reactive species

James W Bruce,Megan Bracken,Edward Evans,Nathan Sherer,Paul Ahlquist
View all publications
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