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AB115170

Anti-ZBTB1 antibody

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(1 Publication)

Rabbit Polyclonal ZBTB1 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZBTB1 aa 650 to C-terminus.

View Alternative Names

KIAA0997, ZBTB1, Zinc finger and BTB domain-containing protein 1

1 Images
Western blot - Anti-ZBTB1 antibody (AB115170)
  • WB

Unknown

Western blot - Anti-ZBTB1 antibody (AB115170)

All lanes:

Western blot - Anti-ZBTB1 antibody (ab115170) at 0.4 µg/mL

Lane 1:

HeLa cell lysate at 50 µg/mL

Lane 2:

HeLa cell lysate at 15 µg/mL

Lane 3:

Jurkat cell lysate at 50 µg/mL

Lane 4:

293T cell lysate at 50 µg/mL

Lane 5:

Mouse NIH3T3 cell lysate at 50 µg/mL

Predicted band size: 82 kDa

false

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ZBTB1 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2K1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Turkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB1 also known as Zinc Finger and BTB Domain-Containing Protein 1 is a transcriptional regulator with a mass of approximately 91 kDa. It contains a BTB (Broad-Complex Tramtrack Bric-à-brac) domain and several zinc finger motifs which are common features for DNA binding and protein-protein interactions. ZBTB1 is mainly expressed in hematopoietic tissues including the thymus and spleen where it influences the development and function of immune cells.
Biological function summary

ZBTB1 plays a vital role in the regulation of gene expression during immune cell differentiation and development. It is part of a protein complex that helps to repress or activate specific target genes influencing the maturation of T cells and B cells. In addition ZBTB1 regulates the expression of genes involved in cell cycle control and apoptosis impacting immune homeostasis and cellular responses to stress.

Pathways

Researchers place ZBTB1 in significant pathways involved with immune system regulation and hematopoiesis. It interacts with proteins in the Notch signaling pathway a critical pathway for T cell development. ZBTB1 also connects with the Wnt signaling pathway where it interacts with other zinc finger proteins to modulate gene expression during early immune cell differentiation.

ZBTB1 mutations have been associated with immunodeficiencies and certain types of cancer such as T-cell acute lymphoblastic leukemia (T-ALL). The protein's connection to improper immune cell differentiation links it to autoimmune disorders as well. Additionally ZBTB1 interacts with tumor suppressor proteins like TP53 influencing cell cycle regulation and apoptosis factors that are often dysregulated in cancers.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a transcriptional repressor (PubMed : 20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed : 21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed : 24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).
See full target information ZBTB1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

British journal of cancer 129:2014-2024 PubMed37914802

2023

Targeting the COMMD4-H2B protein complex in lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ming Tang,Joshua T Burgess,Mark Fisher,Didier Boucher,Emma Bolderson,Neha S Gandhi,Kenneth J O'Byrne,Derek J Richard,Amila Suraweera
View all publications
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Product promise

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