AB106536

Anti-ZBTB3 antibody

Name: Anti-ZBTB3 antibody (ab106536) | Abcam
Brand: Abcam Limited
SKU: AB106536
Price: 520 USD
Availability: InStock

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(5 Publications )

Rabbit Polyclonal ZBTB3 antibody. Suitable for WB and reacts with Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ZBTB3.

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Western blot - Anti-ZBTB3 antibody (AB106536)

Lane 1:

Western blot - Anti-ZBTB3 antibody (ab106536) at 1 µg/mL

Lane 2:

Western blot - Anti-ZBTB3 antibody (ab106536) at 2 µg/mL

All lanes:

Rat brain lysate at 15 µg

Predicted band size: 61 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Synthetic Peptide within Human ZBTB3. The exact immunogen used to generate this antibody is proprietary information.

Q9H5J0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Product details

Predicted to not cross-react with other ZBTB protein family members.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

Up to 12 months

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB3 also known as zinc finger and BTB domain-containing protein 3 is a transcription factor with a molecular weight of approximately 70 kDa. This protein plays a role in DNA binding and gene regulation. ZBTB3 is expressed in various tissues including the liver and testis where it influences developmental and physiological processes. It contains zinc finger motifs that enable it to bind to specific DNA sequences modulating transcriptional activities.

Biological function summary

The zinc finger motifs and BTB domain in ZBTB3 are significant for its role as a transcriptional regulator. Through these domains ZBTB3 interacts with DNA and possibly other transcription factors as part of regulatory complexes impacting gene expression related to cell growth and differentiation. It influences cellular processes such as apoptosis and proliferation. Moreover ZBTB3 has been studied for its potential involvement in maintaining cellular homeostasis through gene network modulation.

Pathways

Several components in gene regulation benefit from the transcriptional network modulated by ZBTB3. It plays a part in the apoptotic and cell cycle pathways affecting cellular longevity and replication. ZBTB3 can interact with or be influenced by proteins such as p53 which is important in apoptosis and cancer progression. Its presence in these pathways highlights its importance in balancing cell survival and death signals often impacting the overall fate of cells in tissue contexts.

Altered expression or function of ZBTB3 has been linked to cancer and metabolic disorders. In particular its dysregulation associates with liver cancer where it might affect cancer cell proliferation through its interactions with proteins like p53. In metabolic contexts alteration in ZBTB3 activity could relate to disorders involving glucose metabolism impacting proteins involved in insulin signaling pathways. Understanding these connections offers potential for therapeutic targeting in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May be involved in transcriptional regulation.

See full target information ZBTB3

Alternative Names

Zinc finger and BTB domain-containing protein 3, ZBTB3

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Publications (5)

Recent publications for all applications. Explore the full listand refine your search

Iranian journal of parasitology 19:131-139 PubMed39011528

2024

Comparative Analysis of and Genes Expression in the Germinative Cells Isolated from Germinal Layer and the Neck Region of .

Applications

Unspecified application

Species

Unspecified reactive species

Amin Yazdani,Narges Khamesi,Alireza Keyhani,Saeid Nasibi,Mohammad Ali Mohammadi,Seyed Mohammad Mousavi,Ali Derakhshani,Majid Fasihi Harandi

Hepatology communications 8: PubMed38285876

2024

Cellular origin and molecular mechanisms of lung metastases in patients with aggressive hepatoblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ruhi Gulati,Maggie Lutz,Margaret Hanlon,Ashley Cast,Rebekah Karns,James Geller,Alex Bondoc,Gregory Tiao,Lubov Timchenko,Nikolai A Timchenko

Nature communications 14:1208 PubMed36869052

2023

An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.

Applications

Unspecified application

Species

Unspecified reactive species

Zhao Wang,Qian Liang,Xinyi Qian,Bolang Hu,Zhanye Zheng,Jianhua Wang,Yuelin Hu,Zhengkai Bao,Ke Zhao,Yao Zhou,Xiangling Feng,Xianfu Yi,Jin Li,Jiandang Shi,Zhe Liu,Jihui Hao,Kexin Chen,Ying Yu,Pak Chung Sham,Wange Lu,Xiaoyan Wang,Weihong Song,Mulin Jun Li

Arthritis & rheumatology (Hoboken, N.J.) 75:574-585 PubMed36245280

2023

Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.

Applications

Unspecified application

Species

Unspecified reactive species

Guojun Hou,Tian Zhou,Ning Xu,Zhihua Yin,Xinyi Zhu,Yutong Zhang,Yange Cui,Jianyang Ma,Yuanjia Tang,Zhaorui Cheng,Yiwei Shen,Yashuo Chen,Ling-Hua Zou,Yong-Fei Wang,Zihang Yin,Ya Guo,Huihua Ding,Zhizhong Ye,Nan Shen

American journal of cancer research 9:2797-2812 PubMed31911863

2019

SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofeng Jin,Jian Wang,Qian Li,Hui Zhuang,Jianye Yang,Zihan Lin,Ting Lin,Zeheng Lv,Liliang Shen,Chunhong Yan,Jingfei Zheng,Jie Zhu,Zhaohui Gong,Chenji Wang,Kun Gao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZBTB3 antibody

Western blot - Anti-ZBTB3 antibody (AB106536)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Alternative Names

Publications (5)

Product promise