Mouse Monoclonal ZBTB39 antibody. Suitable for ICC, Flow Cyt, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZBTB39.
Images
![Immunocytochemistry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (AB277109), expandable thumbnail](https://content.abcam.com/products/images/zbtb39-antibody-pcrp-zmym3-2f10-ab277109--immunocytochemistry-img19778.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (AB277109)")
![Flow Cytometry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (AB277109), expandable thumbnail](https://content.abcam.com/products/images/zbtb39-antibody-pcrp-zmym3-2f10-ab277109--flow-cytometry-img63647.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (AB277109)")
![Protein Array - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (AB277109), expandable thumbnail](https://content.abcam.com/products/images/zbtb39-antibody-pcrp-zmym3-2f10-ab277109--protein-array-img125086.jpg/_jcr_content/renditions/webp-475.webp "Protein Array - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (AB277109)")
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99.9% PBS, 0.05% BSA- Form
Liquid
- Clonality
Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human ZBTB39. Database link O15060
Reactivity data
Select an application| ICC | Flow Cyt | Protein Array | |
|---|---|---|---|
| Human | Tested | Tested | Expected |
| Recombinant full length protein - Human | Not recommended | Not recommended | Tested |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1-2 µg/mL | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1-2 µg for 106 Cells | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
Protein Array
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant full length protein - Human | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
1 products for Alternative Version
Alternative names
Zinc finger and BTB domain-containing protein 39, KIAA0352, ZBTB39
Recommended products
Mouse Monoclonal ZBTB39 antibody. Suitable for ICC, Flow Cyt, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZBTB39.
Alternative names
Zinc finger and BTB domain-containing protein 39, KIAA0352, ZBTB39
Key facts
- Isotype
IgG2b
- Host species
Mouse
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99.9% PBS, 0.05% BSA- Form
Liquid
- Clonality
Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human ZBTB39. Database link O15060
- Clone number
PCRP-ZMYM3-2F10
- Purification technique
Affinity purification Protein A/G
- Concentration
- Purification notes
Purified from bioreactor concentrate
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- Activity summary
ZBTB39 also known as Zinc Finger and BTB Domain-Containing 39 is a transcription factor that plays a role in gene expression regulation. This protein has a molecular mass of approximately 67 kDa. ZBTB39 contains a BTB/POZ domain and zinc finger motifs which enable its interaction with DNA. Expressed in different tissues ZBTB39 shows higher expression levels in the liver and diverse regions of the brain. It functions by binding to specific DNA sequences influencing the transcriptional activity of target genes.
- Biological function summary
ZBTB39 modulates various cellular processes including cell proliferation and differentiation. It often acts as a transcriptional repressor although it may also activate gene expression in certain contexts. As part of a larger transcriptional regulatory complex ZBTB39 interacts with other proteins to influence cell cycle control and apoptotic pathways. By regulating these pathways ZBTB39 plays a significant role in maintaining cellular homeostasis.
- Pathways
ZBTB39 engages in cell signaling pathways that are important for development and immune response. It is associated with the Wnt signaling pathway which plays an important role in cell fate determination and migration. Interaction with proteins like BCL6 in these pathways suggests ZBTB39's involvement in transcriptional repression mechanisms. Additionally ZBTB39 may link with pathways controlling apoptosis further implicating its importance in controlling cell survival and death.
- Associated diseases and disorders
ZBTB39 has been implicated in cancer and neurodegenerative diseases. Its dysregulation is linked to tumorigenesis particularly in cancers where transcriptional repression is important. The protein's interaction with BCL6 known for its role in lymphoid cancers suggests potential pathways for oncogenesis. Furthermore changes in ZBTB39 expression patterns might contribute to neurodegenerative conditions where it could interact with proteins involved in neuronal cell survival and apoptosis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
![Immunocytochemistry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109), expandable thumbnail](https://content.abcam.com/products/images/zbtb39-antibody-pcrp-zmym3-2f10-ab277109--immunocytochemistry-img19778.jpg "Immunocytochemistry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109)")
Immunocytochemistry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109)
Immunofluorescence analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling ZBTB39 with ab277109 at 2 μg/ml, followed by goat anti-mouse IgG-CF488 (green); phalloidin counterstain (red).
![Flow Cytometry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109), expandable thumbnail](https://content.abcam.com/products/images/zbtb39-antibody-pcrp-zmym3-2f10-ab277109--flow-cytometry-img63647.jpg "Flow Cytometry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109)")
Flow Cytometry - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109)
Flow cytometry analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling ZBTB39 using ab277109 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
![Protein Array - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109), expandable thumbnail](https://content.abcam.com/products/images/zbtb39-antibody-pcrp-zmym3-2f10-ab277109--protein-array-img125086.jpg "Protein Array - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109)")
Protein Array - Anti-ZBTB39 antibody [PCRP-ZMYM3-2F10] (ab277109)
Analysis of Protein Array containing more than 19,000 full-length human proteins using ab277109.
Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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