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AB190185

Anti-ZBTB40 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal ZBTB40 antibody. C-terminal. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZBTB40 aa 950 to C-terminus.

View Alternative Names

KIAA0478, ZBTB40, Zinc finger and BTB domain-containing protein 40

1 Images
Western blot - Anti-ZBTB40 antibody - C-terminal (AB190185)
  • WB

Supplier Data

Western blot - Anti-ZBTB40 antibody - C-terminal (AB190185)

All lanes:

Western blot - Anti-ZBTB40 antibody - C-terminal (ab190185) at 1/2000 dilution

Lane 1:

U2OS cell lysate at 40 µg

Lane 2:

U2OS cells transfected with ZBTB40 siRNA at 40 µg

Lane 3:

Mouse embrio fibroblasts (MEFs) cell lysate at 40 µg

Lane 4:

INS1 cell lysate at 40 µg

Predicted band size: 138 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ZBTB40 aa 950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NUA8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.05% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB40 also known as Zinc Finger and BTB Domain-Containing Protein 40 functions mainly as a transcription factor involved in gene regulation. This protein has a molecular weight of approximately 87 kDa. Researchers have observed its expression in various tissues though it is found at higher levels in skeletal tissues. The presence of zinc finger domains suggests its role in DNA binding influencing the transcription of specific genes.
Biological function summary

ZBTB40 participates in bone-related functions. It is not known to be part of any complex. Scientists have associated it with osteoblast differentiation and bone formation indicating its role in skeletal development. The regulation of genes by ZBTB40 influences cellular processes that contribute to the structural and functional integrity of bone tissue.

Pathways

ZBTB40's activities align with bone morphogenetic protein (BMP) signaling and Wnt signaling pathways. These pathways are critical for bone growth and remodeling. ZBTB40 interacts with proteins involved in these pathways such as BMPs and Wnt family proteins modulating their effects downstream. These interactions help coordinate the complex signaling necessary for maintaining bone health.

ZBTB40 has links to osteoporosis and skeletal dysplasia. Researchers have studied its regulatory functions in bone mineral density connecting it to conditions of bone fragility and poor bone development. The protein also interacts with RUNX2 an important factor involved in skeletal system health exacerbating or mitigating disease progression based on ZBTB40's activity levels. Understanding these connections provides insights into potential therapeutic targets for these bone-related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information ZBTB40
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 53: PubMed40548939

2025

USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Mengfan Tang,Siting Li,Ziqiang Zhu,Chao Wang,Shuai Ding,Huimin Zhang,Min Huang,Sarah Keast,Zhen Chen,Ling Yin,Litong Nie,Dan Su,Xu Feng,Junjie Chen

PLoS genetics 16:e1008805 PubMed32497039

2020

Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.

Applications

WB

Species

Mouse

Madison L Doolittle,Gina M Calabrese,Larry D Mesner,Dana A Godfrey,Robert D Maynard,Cheryl L Ackert-Bicknell,Charles R Farber
View all publications
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