Anti-ZBTB40 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZBTB40 also known as Zinc Finger and BTB Domain-Containing Protein 40 functions mainly as a transcription factor involved in gene regulation. This protein has a molecular weight of approximately 87 kDa. Researchers have observed its expression in various tissues though it is found at higher levels in skeletal tissues. The presence of zinc finger domains suggests its role in DNA binding influencing the transcription of specific genes.

Biological function summary

ZBTB40 participates in bone-related functions. It is not known to be part of any complex. Scientists have associated it with osteoblast differentiation and bone formation indicating its role in skeletal development. The regulation of genes by ZBTB40 influences cellular processes that contribute to the structural and functional integrity of bone tissue.

Pathways

ZBTB40's activities align with bone morphogenetic protein (BMP) signaling and Wnt signaling pathways. These pathways are critical for bone growth and remodeling. ZBTB40 interacts with proteins involved in these pathways such as BMPs and Wnt family proteins modulating their effects downstream. These interactions help coordinate the complex signaling necessary for maintaining bone health.

Associated diseases and disorders

ZBTB40 has links to osteoporosis and skeletal dysplasia. Researchers have studied its regulatory functions in bone mineral density connecting it to conditions of bone fragility and poor bone development. The protein also interacts with RUNX2 an important factor involved in skeletal system health exacerbating or mitigating disease progression based on ZBTB40's activity levels. Understanding these connections provides insights into potential therapeutic targets for these bone-related conditions.