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AB277100

Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8]

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(1 Publication)

Mouse Monoclonal ZBTB46 antibody. Suitable for Flow Cyt, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZBTB46.

View Alternative Names

BTBD4, ZNF340, ZBTB46, Zinc finger and BTB domain-containing protein 46, BTB/POZ domain-containing protein 4, Zinc finger protein 340

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8] (AB277100)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8] (AB277100)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for ZBTB46 using ab277100 at 2 μg/ml in immunohistochemical analysis.

Flow Cytometry - Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8] (AB277100)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8] (AB277100)

Flow cytometry analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling ZBTB46 using ab277100 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

Protein Array - Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8] (AB277100)
  • Protein Array

Unknown

Protein Array - Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8] (AB277100)

Analysis of Protein Array containing more than 19,000 full-length human proteins using ab277100.

Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

PCRP-ZBTB46-2B8

Isotype

IgG2a

Carrier free

No

Reacts with

Human

Applications

IHC-P, Flow Cyt, Protein Array

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ZBTB46.

Q86UZ6

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Complementary Products

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Multiplex Kits

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Multiplex Kits

AB133998

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Proteins & Peptides

AB307487

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>", "ProteinArray-species-checked": "guaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "ProteinArray-species-checked": "predicted", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "ProteinArray-species-checked": "predicted", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from bioreactor concentrate
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB46 also known as zbtb46 Zfp405 or BTBD4 is a transcription factor with a molecular weight of approximately 60 kDa. It belongs to the BTB-ZF protein family and mainly expresses in dendritic cells and endothelial cells. This protein plays an important role in regulating gene expression by binding to DNA sequences through its zinc-finger domains. ZBTB46 serves as a specific marker for conventional dendritic cells which distinguishes them from other immune cells.
Biological function summary

The functioning of ZBTB46 involves the regulation of immune system responses and cellular development processes. ZBTB46 does not form a larger protein complex. Its activity impacts the maturation and function of certain immune cells especially those involved in presenting antigens to T cells. Through this regulation ZBTB46 influences various immune processes including inflammation and the maintenance of immune homeostasis helping to prevent excessive immune responses.

Pathways

ZBTB46 plays a role in the innate immune response and hematopoiesis. In the innate immune response it helps dictate the development of dendritic cells interacting with key proteins such as ID2 and E2-2. During hematopoiesis it guides the differentiation of multipotent progenitors toward specific cell lineages maintaining balanced production of immune cells. ZBTB46’s involvement in these pathways confirms its importance in both immune system and blood cell development.

ZBTB46 has associations with immunological disorders such as autoimmune diseases and inflammatory conditions. Dysregulation of ZBTB46 expression can contribute to abnormal immune responses potentially leading to chronic inflammation or autoimmunity. In conditions like systemic lupus erythematosus ZBTB46 dysregulation may occur in connection with proteins like STAT3 influencing disease progression and severity. This establishes ZBTB46 as a potential target for therapeutic interventions aiming to modulate immune function in such disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription regulator that mediates differentiation of conventional and non-conventional dendritic cells, and which is involved in tolerance to gut microbiota. Together with RORgammaT (RORC), specifically expressed in type 3 innate lymphoid cells (ILC3s) that are required for tolerance to gut microbiota, to mediate differentiation of peripherally-induced regulatory T-cells (pTreg), which suppress inflammatory responses to commensal microorganisms. Functions as a transcription corepressor for PRDM1.
See full target information ZBTB46
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of gastrointestinal oncology 11:1186-1199 PubMed33456992

2021

CircBACH1/let-7a-5p axis enhances the proliferation and metastasis of colorectal cancer by upregulating CREB5 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jutang Li,Qian Tang,Wei Dong,Yizhou Wang
View all publications
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Product promise

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