Anti-ZBTB46 antibody [PCRP-ZBTB46-2B8]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ZBTB46 also known as zbtb46 Zfp405 or BTBD4 is a transcription factor with a molecular weight of approximately 60 kDa. It belongs to the BTB-ZF protein family and mainly expresses in dendritic cells and endothelial cells. This protein plays an important role in regulating gene expression by binding to DNA sequences through its zinc-finger domains. ZBTB46 serves as a specific marker for conventional dendritic cells which distinguishes them from other immune cells.

Biological function summary

The functioning of ZBTB46 involves the regulation of immune system responses and cellular development processes. ZBTB46 does not form a larger protein complex. Its activity impacts the maturation and function of certain immune cells especially those involved in presenting antigens to T cells. Through this regulation ZBTB46 influences various immune processes including inflammation and the maintenance of immune homeostasis helping to prevent excessive immune responses.

Pathways

ZBTB46 plays a role in the innate immune response and hematopoiesis. In the innate immune response it helps dictate the development of dendritic cells interacting with key proteins such as ID2 and E2-2. During hematopoiesis it guides the differentiation of multipotent progenitors toward specific cell lineages maintaining balanced production of immune cells. ZBTB46’s involvement in these pathways confirms its importance in both immune system and blood cell development.

Associated diseases and disorders

ZBTB46 has associations with immunological disorders such as autoimmune diseases and inflammatory conditions. Dysregulation of ZBTB46 expression can contribute to abnormal immune responses potentially leading to chronic inflammation or autoimmunity. In conditions like systemic lupus erythematosus ZBTB46 dysregulation may occur in connection with proteins like STAT3 influencing disease progression and severity. This establishes ZBTB46 as a potential target for therapeutic interventions aiming to modulate immune function in such disorders.