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AB106562

Anti-ZBTB5 antibody

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(1 Publication)

Rabbit Polyclonal ZBTB5 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZBTB5.

View Alternative Names

KIAA0354, ZBTB5, Zinc finger and BTB domain-containing protein 5

1 Images
Western blot - Anti-ZBTB5 antibody (AB106562)
  • WB

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Western blot - Anti-ZBTB5 antibody (AB106562)

Lane 1:

Western blot - Anti-ZBTB5 antibody (ab106562) at 1 µg/mL

Lane 2:

Western blot - Anti-ZBTB5 antibody (ab106562) at 2 µg/mL

All lanes:

Mouse brain tissue lysate at 15 µg

Predicted band size: 74 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ZBTB5. The exact immunogen used to generate this antibody is proprietary information.

O15062

Specificity

ab106562 will recognize both isoforms of ZBTB5. This antibody is predicted to not cross-react with other ZBTB protein family members.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZBTB5 also known as Zinc Finger and BTB Domain Containing 5 is a transcription factor involved in the regulation of gene expression. It plays a significant role in the transcriptional repression of target genes. ZBTB5 has a molecular mass of around 65 kDa. This protein is expressed in various tissues including the heart brain and skeletal muscle. By binding to specific DNA sequences ZBTB5 can alter transcriptional activity affecting downstream gene networks.
Biological function summary

ZBTB5 participates in the regulation of cellular processes such as cell cycle progression and apoptosis. It functions within a complex involving other transcriptional regulators which modulate gene expression during cell proliferation. This protein can act as a transcriptional repressor whereby it binds to target gene promoters modulating the transcription rate according to cellular needs. Its presence influences cellular homeostasis making it essential for normal cell function.

Pathways

ZBTB5 engages in significant transcriptional regulatory pathways including the cell cycle control and apoptosis pathways. It interacts with key proteins within these pathways such as E2F1 and p53 influencing their activity and stability. Through these interactions ZBTB5 contributes to the control of cell division and programmed cell death thereby maintaining the balance between cell proliferation and apoptosis.

ZBTB5 has connections to cancer and neurodegenerative diseases. Altered expression levels of ZBTB5 are observed in various types of cancer where it can disrupt normal cell cycle regulation. Its interaction with p53 links it to tumorigenesis as p53 is a well-known tumor suppressor. In neurodegenerative diseases ZBTB5's role in apoptosis could influence neuronal cell death potentially implicating it in conditions like Alzheimer's disease. Understanding ZBTB5's interactions in these disorders may provide new insights into therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation.
See full target information ZBTB5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 12:714785 PubMed34408668

2021

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marisela Rodriguez,Jiyuan Chen,Pritesh P Jain,Aleksandra Babicheva,Mingmei Xiong,Jifeng Li,Ning Lai,Tengteng Zhao,Moises Hernandez,Angela Balistrieri,Sophia Parmisano,Tatum Simonson,Ellen Breen,Daniela Valdez-Jasso,Patricia A Thistlethwaite,John Y-J Shyy,Jian Wang,Joe G N Garcia,Ayako Makino,Jason X-J Yuan
View all publications
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Product promise

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