Rabbit Polyclonal ZBTB5 antibody. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human ZBTB5.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ZBTB5. The exact immunogen used to generate this antibody is proprietary information. Database link O15062
Reactivity data
Select an application| WB | |
|---|---|
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1.00000-2.00000 µg/mL | Notes - |
Alternative names
KIAA0354, ZBTB5, Zinc finger and BTB domain-containing protein 5
Recommended products
Rabbit Polyclonal ZBTB5 antibody. Suitable for WB and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human ZBTB5.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ZBTB5. The exact immunogen used to generate this antibody is proprietary information. Database link O15062
- Purification technique
- Affinity purification Immunogen
- Specificity
ab106562 will recognize both isoforms of ZBTB5. This antibody is predicted to not cross-react with other ZBTB protein family members.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ZBTB5 also known as Zinc Finger and BTB Domain Containing 5 is a transcription factor involved in the regulation of gene expression. It plays a significant role in the transcriptional repression of target genes. ZBTB5 has a molecular mass of around 65 kDa. This protein is expressed in various tissues including the heart brain and skeletal muscle. By binding to specific DNA sequences ZBTB5 can alter transcriptional activity affecting downstream gene networks.
- Biological function summary
ZBTB5 participates in the regulation of cellular processes such as cell cycle progression and apoptosis. It functions within a complex involving other transcriptional regulators which modulate gene expression during cell proliferation. This protein can act as a transcriptional repressor whereby it binds to target gene promoters modulating the transcription rate according to cellular needs. Its presence influences cellular homeostasis making it essential for normal cell function.
- Pathways
ZBTB5 engages in significant transcriptional regulatory pathways including the cell cycle control and apoptosis pathways. It interacts with key proteins within these pathways such as E2F1 and p53 influencing their activity and stability. Through these interactions ZBTB5 contributes to the control of cell division and programmed cell death thereby maintaining the balance between cell proliferation and apoptosis.
- Associated diseases and disorders
ZBTB5 has connections to cancer and neurodegenerative diseases. Altered expression levels of ZBTB5 are observed in various types of cancer where it can disrupt normal cell cycle regulation. Its interaction with p53 links it to tumorigenesis as p53 is a well-known tumor suppressor. In neurodegenerative diseases ZBTB5's role in apoptosis could influence neuronal cell death potentially implicating it in conditions like Alzheimer's disease. Understanding ZBTB5's interactions in these disorders may provide new insights into therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ZBTB5 antibody (ab106562)
Lane 1: Western blot - Anti-ZBTB5 antibody (ab106562) at 1 µg/mL
Lane 2: Western blot - Anti-ZBTB5 antibody (ab106562) at 2 µg/mL
All lanes: Mouse brain tissue lysate at 15 µg
Predicted band size: 74 kDa
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